SPIRONOLACTONE

BannedCAS 52-01-724 regulations across 24 markets

SPIRONOLACTONE is a cosmetic ingredient classified as Not Reported. Also known as CAS 52-01-7. It is regulated in 24 markets including UAE, Armenia, Bahrain.

Also Known As

CAS Number
52-01-7

Market Overview — 29 Markets

European Union1
United Kingdom1
United States
California1
Maryland
Washington
Canada1
Brazil1
South Korea1
Japan
Taiwan1
Australia
Singapore1
Malaysia1
Thailand1
Indonesia1
Vietnam1
Philippines1
UAE1
Saudi Arabia1
Qatar1
Oman1
Kuwait1
Bahrain1
Russia1
Belarus1
Kazakhstan1
Armenia1
Kyrgyzstan1

Detailed Regulations

Europe2 regulations
European UnionBannedAnnex II #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: EC 1223/2009 Annex II

United KingdomBannedAnnex II #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: UK retained EC 1223/2009 Annex II

Americas3 regulations
CaliforniaRestrictedAnnex PROP65
Chemical name
Spironolactone
CAS
52-01-7
Conditions of use
Prop 65 Warning Required: cancer

Source: California Prop 65

CanadaBannedAnnex Table 1 (Prohibited)
Chemical name
Spironolactone
CAS
52-01-7
Conditions of use
Prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

BrazilBannedAnnex RDC_529 #4
Chemical name
Espironolactona*
CAS
52-01-7

Source: ANVISA RDC 529

East Asia & Oceania2 regulations
South KoreaBannedAnnex banned #M400
Chemical name
Spironolactone

Source: MFDS Korea Cosmetics Regulation

TaiwanBannedAnnex Prohibited Ingredients List #403
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: TFDA Cosmetics Regulations

ASEAN6 regulations
SingaporeBannedAnnex ACD Annex II (Prohibited) #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

MalaysiaBannedAnnex ACD Annex II (Prohibited) #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

ThailandBannedAnnex ACD Annex II (Prohibited) #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

IndonesiaBannedAnnex ACD Annex II (Prohibited) #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

VietnamBannedAnnex ACD Annex II (Prohibited) #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

PhilippinesBannedAnnex ACD Annex II (Prohibited) #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

GCC6 regulations
UAEBannedAnnex II #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: GSO 1943:2024 (based on EU 1223/2009 II)

Saudi ArabiaBannedAnnex II #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: GSO 1943:2024 (based on EU 1223/2009 II)

QatarBannedAnnex II #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: GSO 1943:2024 (based on EU 1223/2009 II)

OmanBannedAnnex II #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: GSO 1943:2024 (based on EU 1223/2009 II)

KuwaitBannedAnnex II #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: GSO 1943:2024 (based on EU 1223/2009 II)

BahrainBannedAnnex II #4
Chemical name
Spironolactone (INN)
CAS
52-01-7

Source: GSO 1943:2024 (based on EU 1223/2009 II)

EAEU5 regulations
RussiaBannedAnnex 1 #4
Chemical name
Спиронолактон (INN)
CAS
52-01-7

Source: TR CU 009/2011 Annex 1 (Prohibited Substances) (Ref 4)

BelarusBannedAnnex 1 #4
Chemical name
Спиронолактон (INN)
CAS
52-01-7

Source: TR CU 009/2011 Annex 1 (Prohibited Substances) (Ref 4)

KazakhstanBannedAnnex 1 #4
Chemical name
Спиронолактон (INN)
CAS
52-01-7

Source: TR CU 009/2011 Annex 1 (Prohibited Substances) (Ref 4)

ArmeniaBannedAnnex 1 #4
Chemical name
Спиронолактон (INN)
CAS
52-01-7

Source: TR CU 009/2011 Annex 1 (Prohibited Substances) (Ref 4)

KyrgyzstanBannedAnnex 1 #4
Chemical name
Спиронолактон (INN)
CAS
52-01-7

Source: TR CU 009/2011 Annex 1 (Prohibited Substances) (Ref 4)

Frequently Asked Questions

Is SPIRONOLACTONE banned in any country?

Yes, SPIRONOLACTONE is banned in UAE, Armenia, Bahrain, Brazil, Belarus, Canada, European Union, Indonesia, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Always check current regulations before formulating products for these markets.

What are the restrictions on SPIRONOLACTONE in cosmetics?

SPIRONOLACTONE is banned in UAE, Armenia, Bahrain, Brazil, Belarus, Canada, European Union, Indonesia, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam and has no specific restrictions in other tracked markets.

Can I use SPIRONOLACTONE in cosmetics?

SPIRONOLACTONE is regulated in 24 markets. It is banned in UAE, Armenia, Bahrain, Brazil, Belarus, Canada, European Union, Indonesia, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Use Formpli's free screening tool to check your full ingredient list against all 26 markets at once.

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This information is for reference only and does not constitute legal or regulatory advice. Regulations change — always verify with official sources and consult a regulatory specialist before exporting cosmetic products. Data sourced from EU COSING, US FDA, Health Canada, MHLW Japan, MFDS Korea, ASEAN ACD, GCC SFDA, TGA Australia, ANVISA Brazil, EAEU TR CU, and Taiwan TFDA.