POLYAMINOPROPYL BIGUANIDE

RestrictedCAS 32289-58-024 regulations across 23 markets

POLYAMINOPROPYL BIGUANIDE is a cosmetic ingredient classified as Preservative. Also known as CAS 32289-58-0. It is regulated in 23 markets including UAE, Armenia, Bahrain.

Also Known As

CAS Number
133029-32-0, 27083-27-8, 28757-47-3, 32289-58-0

Market Overview — 29 Markets

European Union1
United Kingdom1
United States
California
Maryland
Washington
Canada
Brazil1
South Korea1
Japan2
Taiwan1
Australia
Singapore1
Malaysia1
Thailand1
Indonesia1
Vietnam1
Philippines1
UAE1
Saudi Arabia1
Qatar1
Oman1
Kuwait1
Bahrain1
Russia1
Belarus1
Kazakhstan1
Armenia1
Kyrgyzstan1

Detailed Regulations

Europe2 regulations
European UnionRestrictedAnnex V #28
Chemical name
Polyhexamethylene biguanide hydrochloride
CAS
32289-58-0 [1]/ 27083-27-8 [2]/ 28757-47-3 [3]/ 133029-32-0 [4]
Max concentration
0.1%
Other conditions
Not to be used in applications that may lead to exposure of the end-user's lungs by inhalation

Source: EC 1223/2009 Annex V

United KingdomRestrictedAnnex V #28
Chemical name
Polyhexamethylene biguanide hydrochloride
CAS
32289-58-0, 27083-27-8, 28757-47-3, 133029-32-0
Max concentration
0,1 %
Conditions of use
Max: 0,1 %
Other conditions
Not to be used in applications that may lead to exposure of the end-user's lungs by inhalation

Source: UK retained EC 1223/2009 Annex V

Americas1 regulation
BrazilRestrictedAnnex RDC_528 #25
Chemical name
Cloridrato de polihexametileno biguanida
CAS
32289-58-0
Max concentration
0,1%
Conditions of use
Limitations: Proibido em produtos cuja aplicação possa conduzir à exposição pela via de inalação.

Source: ANVISA RDC 528

East Asia & Oceania4 regulations
South KoreaRestrictedAnnex restricted #M1087
Chemical name
Polyaminopropyl Biguanide
Conditions of use
* 배합한도 : 0.05% 에어로졸(스프레이에 한함) 제품에는 사용금지

Source: MFDS Korea Cosmetics Regulation

JapanRestrictedAnnex Appendix 3 (Preservatives) #3-2
Chemical name
Polyaminopropyl biguanide
Max concentration
0.1%
Product type
Leave-on (cosmetics not washed away)

Source: MHLW Standards for Cosmetics (Notification No.331 of 2000)

JapanRestrictedAnnex Appendix 3 (Preservatives) #3-2
Chemical name
Polyaminopropyl biguanide
Max concentration
0.1%
Product type
Rinse-off (cosmetics washed away after use)

Source: MHLW Standards for Cosmetics (Notification No.331 of 2000)

TaiwanRestrictedAnnex Preservatives List #39
Chemical name
Poly(methylene),.alpha.,.ome-ga.-bis[[[(aminoiminomethyl)amino]iminomethyl]amino]-, dihydrochloride
CAS
32289-58-0/ 133029-32-0/ 28757-47-3/ 27083-27-8
Max concentration
0.3 %

Source: TFDA Cosmetics Regulations

ASEAN6 regulations
SingaporeRestrictedAnnex ACD Annex VI (Preservatives) #28
Chemical name
Poly(1-hexamethylenebiguanide hydrochloride) / Polyaminopropyl biguanide CAS 32289-58-0, 27083-27-8, 28757-47-3, 133029-32-0
CAS
32289-58-0
Max concentration
0.1%
Conditions of use
Not to be used in applications that may lead to exposure of the end- user's lungs by inhalation'

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

MalaysiaRestrictedAnnex ACD Annex VI (Preservatives) #28
Chemical name
Poly(1-hexamethylenebiguanide hydrochloride) / Polyaminopropyl biguanide CAS 32289-58-0, 27083-27-8, 28757-47-3, 133029-32-0
CAS
32289-58-0
Max concentration
0.1%
Conditions of use
Not to be used in applications that may lead to exposure of the end- user's lungs by inhalation'

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

ThailandRestrictedAnnex ACD Annex VI (Preservatives) #28
Chemical name
Poly(1-hexamethylenebiguanide hydrochloride) / Polyaminopropyl biguanide CAS 32289-58-0, 27083-27-8, 28757-47-3, 133029-32-0
CAS
32289-58-0
Max concentration
0.1%
Conditions of use
Not to be used in applications that may lead to exposure of the end- user's lungs by inhalation'

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

IndonesiaRestrictedAnnex ACD Annex VI (Preservatives) #28
Chemical name
Poly(1-hexamethylenebiguanide hydrochloride) / Polyaminopropyl biguanide CAS 32289-58-0, 27083-27-8, 28757-47-3, 133029-32-0
CAS
32289-58-0
Max concentration
0.1%
Conditions of use
Not to be used in applications that may lead to exposure of the end- user's lungs by inhalation'

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

VietnamRestrictedAnnex ACD Annex VI (Preservatives) #28
Chemical name
Poly(1-hexamethylenebiguanide hydrochloride) / Polyaminopropyl biguanide CAS 32289-58-0, 27083-27-8, 28757-47-3, 133029-32-0
CAS
32289-58-0
Max concentration
0.1%
Conditions of use
Not to be used in applications that may lead to exposure of the end- user's lungs by inhalation'

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

PhilippinesRestrictedAnnex ACD Annex VI (Preservatives) #28
Chemical name
Poly(1-hexamethylenebiguanide hydrochloride) / Polyaminopropyl biguanide CAS 32289-58-0, 27083-27-8, 28757-47-3, 133029-32-0
CAS
32289-58-0
Max concentration
0.1%
Conditions of use
Not to be used in applications that may lead to exposure of the end- user's lungs by inhalation'

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

GCC6 regulations
UAERestrictedAnnex V #28
Chemical name
Polyhexamethylene biguanide hydrochloride
CAS
32289-58-0 [1]/ 27083-27-8 [2]/ 28757-47-3 [3]/ 133029-32-0 [4]
Max concentration
0.1%
Other conditions
Not to be used in applications that may lead to exposure of the end-user's lungs by inhalation

Source: GSO 1943:2024 (based on EU 1223/2009 V)

Saudi ArabiaRestrictedAnnex V #28
Chemical name
Polyhexamethylene biguanide hydrochloride
CAS
32289-58-0 [1]/ 27083-27-8 [2]/ 28757-47-3 [3]/ 133029-32-0 [4]
Max concentration
0.1%
Other conditions
Not to be used in applications that may lead to exposure of the end-user's lungs by inhalation

Source: GSO 1943:2024 (based on EU 1223/2009 V)

QatarRestrictedAnnex V #28
Chemical name
Polyhexamethylene biguanide hydrochloride
CAS
32289-58-0 [1]/ 27083-27-8 [2]/ 28757-47-3 [3]/ 133029-32-0 [4]
Max concentration
0.1%
Other conditions
Not to be used in applications that may lead to exposure of the end-user's lungs by inhalation

Source: GSO 1943:2024 (based on EU 1223/2009 V)

OmanRestrictedAnnex V #28
Chemical name
Polyhexamethylene biguanide hydrochloride
CAS
32289-58-0 [1]/ 27083-27-8 [2]/ 28757-47-3 [3]/ 133029-32-0 [4]
Max concentration
0.1%
Other conditions
Not to be used in applications that may lead to exposure of the end-user's lungs by inhalation

Source: GSO 1943:2024 (based on EU 1223/2009 V)

KuwaitRestrictedAnnex V #28
Chemical name
Polyhexamethylene biguanide hydrochloride
CAS
32289-58-0 [1]/ 27083-27-8 [2]/ 28757-47-3 [3]/ 133029-32-0 [4]
Max concentration
0.1%
Other conditions
Not to be used in applications that may lead to exposure of the end-user's lungs by inhalation

Source: GSO 1943:2024 (based on EU 1223/2009 V)

BahrainRestrictedAnnex V #28
Chemical name
Polyhexamethylene biguanide hydrochloride
CAS
32289-58-0 [1]/ 27083-27-8 [2]/ 28757-47-3 [3]/ 133029-32-0 [4]
Max concentration
0.1%
Other conditions
Not to be used in applications that may lead to exposure of the end-user's lungs by inhalation

Source: GSO 1943:2024 (based on EU 1223/2009 V)

EAEU5 regulations
RussiaRestrictedAnnex 4 #28
Chemical name
Полигексаметилен бигуанид гидрохлорид
CAS
32289-58-0,27083-27-8,28757-47-3,133029-32-0
Max concentration
0,1 процента
Other conditions
Не использовать в формах, которые могут привести к воздействию на легкие конечного потребителя при вдыхании.

Source: TR CU 009/2011 Annex 4 (Preservatives) (Ref 28)

BelarusRestrictedAnnex 4 #28
Chemical name
Полигексаметилен бигуанид гидрохлорид
CAS
32289-58-0,27083-27-8,28757-47-3,133029-32-0
Max concentration
0,1 процента
Other conditions
Не использовать в формах, которые могут привести к воздействию на легкие конечного потребителя при вдыхании.

Source: TR CU 009/2011 Annex 4 (Preservatives) (Ref 28)

KazakhstanRestrictedAnnex 4 #28
Chemical name
Полигексаметилен бигуанид гидрохлорид
CAS
32289-58-0,27083-27-8,28757-47-3,133029-32-0
Max concentration
0,1 процента
Other conditions
Не использовать в формах, которые могут привести к воздействию на легкие конечного потребителя при вдыхании.

Source: TR CU 009/2011 Annex 4 (Preservatives) (Ref 28)

ArmeniaRestrictedAnnex 4 #28
Chemical name
Полигексаметилен бигуанид гидрохлорид
CAS
32289-58-0,27083-27-8,28757-47-3,133029-32-0
Max concentration
0,1 процента
Other conditions
Не использовать в формах, которые могут привести к воздействию на легкие конечного потребителя при вдыхании.

Source: TR CU 009/2011 Annex 4 (Preservatives) (Ref 28)

KyrgyzstanRestrictedAnnex 4 #28
Chemical name
Полигексаметилен бигуанид гидрохлорид
CAS
32289-58-0,27083-27-8,28757-47-3,133029-32-0
Max concentration
0,1 процента
Other conditions
Не использовать в формах, которые могут привести к воздействию на легкие конечного потребителя при вдыхании.

Source: TR CU 009/2011 Annex 4 (Preservatives) (Ref 28)

Frequently Asked Questions

Is POLYAMINOPROPYL BIGUANIDE banned in any country?

POLYAMINOPROPYL BIGUANIDE is not banned in any of the 26 markets tracked by Formpli. However, it may be subject to restrictions or conditions of use in some markets.

What are the restrictions on POLYAMINOPROPYL BIGUANIDE in cosmetics?

POLYAMINOPROPYL BIGUANIDE is restricted or has conditions of use in UAE, Armenia, Bahrain, Brazil, Belarus, European Union, Indonesia, Japan, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Restrictions may include maximum concentration limits, product type limitations, or mandatory labeling requirements. See the detailed regulations above for specifics.

Can I use POLYAMINOPROPYL BIGUANIDE in cosmetics?

POLYAMINOPROPYL BIGUANIDE is regulated in 23 markets. It has restrictions in UAE, Armenia, Bahrain, Brazil, Belarus, European Union, Indonesia, Japan, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Use Formpli's free screening tool to check your full ingredient list against all 26 markets at once.

Screen POLYAMINOPROPYL BIGUANIDE with your full formula

Paste your entire ingredient list and get a compliance report across 26 markets — free, no signup.

Check Ingredients Free

This information is for reference only and does not constitute legal or regulatory advice. Regulations change — always verify with official sources and consult a regulatory specialist before exporting cosmetic products. Data sourced from EU COSING, US FDA, Health Canada, MHLW Japan, MFDS Korea, ASEAN ACD, GCC SFDA, TGA Australia, ANVISA Brazil, EAEU TR CU, and Taiwan TFDA.