PIROCTONE OLAMINE

RestrictedCAS 68890-66-433 regulations across 18 markets

PIROCTONE OLAMINE is a cosmetic ingredient classified as Anti-Seborrheic. Also known as CAS 68890-66-4. It is regulated in 18 markets including UAE, Bahrain, Brazil.

Also Known As

CAS Number
50650-76-5, 68890-66-4

Market Overview — 29 Markets

European Union2
United Kingdom3
United States
California
Maryland
Washington
Canada
Brazil1
South Korea1
Japan1
Taiwan1
Australia
Singapore2
Malaysia2
Thailand2
Indonesia2
Vietnam2
Philippines2
UAE2
Saudi Arabia2
Qatar2
Oman2
Kuwait2
Bahrain2
Russia
Belarus
Kazakhstan
Armenia
Kyrgyzstan

Detailed Regulations

Europe5 regulations
European UnionRestrictedAnnex III #61
Chemical name
Monoalkylamines, monoalkanolamines and their salts
CAS
68890-66-4
Max concentration
Maximum secondary amine content: 0.5%
Other conditions
- Do not use with nitrosating systems - Minimum purity: 99% - Maximum secondary amine content: 0.5% (applies to raw materials) - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers

Source: EC 1223/2009 Annex III

European UnionRestrictedAnnex V #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt
CAS
50650-76-5 / 68890-66-4
Max concentration
a) 1.0% b) 0.5%
Product type
a) Rinse-off products b) Other products

Source: EC 1223/2009 Annex V

United KingdomRestrictedAnnex III #61
Chemical name
Monoalkylamines, monoalkanolamines and their salts
Max concentration
Maximum secondary amine content: 0,5 %
Conditions of use
Max: Maximum secondary amine content: 0,5 %
Other conditions
Not to be used with nitrosating systems- Minimum purity: 99 %Maximum secondary amine content: 0,5 % (applies to raw materials)Maximum nitrosamine content: 50 μg/kgKeep in nitrite-free containers

Source: UK retained EC 1223/2009 Annex III

United KingdomRestrictedAnnex V #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl) 2-pyridon and its monoethanolamine salt
CAS
50650-76-5, 68890-66-4
Max concentration
0,5 %
Product type
Other products
Conditions of use
Max: 0,5 %

Source: UK retained EC 1223/2009 Annex V

United KingdomRestrictedAnnex V #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl) 2-pyridon and its monoethanolamine salt
CAS
50650-76-5, 68890-66-4
Max concentration
1,0 %
Product type
Rinse-off products
Conditions of use
Max: 1,0 %

Source: UK retained EC 1223/2009 Annex V

Americas1 regulation
BrazilRestrictedAnnex RDC_528 #33
Chemical name
1-hidroxi-4-metil-6- (2,4,4-trimetilpentil )-2-piridona e seus sais de monoetanolamina (Octopirox)
CAS
50650-76-5
Max concentration
a) 1% em produtos que se enxáguem. b) 0,5% em produtos que não se enxáguem.

Source: ANVISA RDC 528

East Asia & Oceania3 regulations
South KoreaRestrictedAnnex restricted #M209
Chemical name
Piroctone Olamine
Conditions of use
* 배합한도 : ∙ 사용 후 씻어내는 제품에 1.0%, ∙ 기타 제품에 0.5%

Source: MFDS Korea Cosmetics Regulation

JapanRestrictedAnnex Appendix 3 (Preservatives) #3-2
Chemical name
Piroctone olamine
Max concentration
0.05%
Product type
Rinse-off (cosmetics washed away after use)

Source: MHLW Standards for Cosmetics (Notification No.331 of 2000)

TaiwanRestrictedAnnex Preservatives List #38
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt
CAS
50650-76-5/ 68890-66-4
Max concentration
(a) 1 % (b) 0.5 %
Product type
(a ) R i n s e-off products (b)Other products

Source: TFDA Cosmetics Regulations

ASEAN12 regulations
SingaporeRestrictedAnnex ACD Annex III (Restricted) #61
Chemical name
monoalkanolamines Monoalkylamines, and their salts
Max concentration
• Do not use with nitrosating systems • Minimum purity: 99% • Maximum secondary amine content : 0.5% (applies to raw materials) • Maximum nitrosamine content: 50  g/kg (21) • Keep in nitrite-free con
Product type
Maximum secondary amine content: 0.5%

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

SingaporeRestrictedAnnex ACD Annex VI (Preservatives) #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt (+) 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon / piroctone Olamine
CAS
50650-76-5
Max concentration
1% 0.5%
Conditions of use
Rinse-off products For other products

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

MalaysiaRestrictedAnnex ACD Annex III (Restricted) #61
Chemical name
monoalkanolamines Monoalkylamines, and their salts
Max concentration
• Do not use with nitrosating systems • Minimum purity: 99% • Maximum secondary amine content : 0.5% (applies to raw materials) • Maximum nitrosamine content: 50  g/kg (21) • Keep in nitrite-free con
Product type
Maximum secondary amine content: 0.5%

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

MalaysiaRestrictedAnnex ACD Annex VI (Preservatives) #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt (+) 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon / piroctone Olamine
CAS
50650-76-5
Max concentration
1% 0.5%
Conditions of use
Rinse-off products For other products

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

ThailandRestrictedAnnex ACD Annex III (Restricted) #61
Chemical name
monoalkanolamines Monoalkylamines, and their salts
Max concentration
• Do not use with nitrosating systems • Minimum purity: 99% • Maximum secondary amine content : 0.5% (applies to raw materials) • Maximum nitrosamine content: 50  g/kg (21) • Keep in nitrite-free con
Product type
Maximum secondary amine content: 0.5%

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

ThailandRestrictedAnnex ACD Annex VI (Preservatives) #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt (+) 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon / piroctone Olamine
CAS
50650-76-5
Max concentration
1% 0.5%
Conditions of use
Rinse-off products For other products

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

IndonesiaRestrictedAnnex ACD Annex III (Restricted) #61
Chemical name
monoalkanolamines Monoalkylamines, and their salts
Max concentration
• Do not use with nitrosating systems • Minimum purity: 99% • Maximum secondary amine content : 0.5% (applies to raw materials) • Maximum nitrosamine content: 50  g/kg (21) • Keep in nitrite-free con
Product type
Maximum secondary amine content: 0.5%

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

IndonesiaRestrictedAnnex ACD Annex VI (Preservatives) #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt (+) 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon / piroctone Olamine
CAS
50650-76-5
Max concentration
1% 0.5%
Conditions of use
Rinse-off products For other products

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

VietnamRestrictedAnnex ACD Annex III (Restricted) #61
Chemical name
monoalkanolamines Monoalkylamines, and their salts
Max concentration
• Do not use with nitrosating systems • Minimum purity: 99% • Maximum secondary amine content : 0.5% (applies to raw materials) • Maximum nitrosamine content: 50  g/kg (21) • Keep in nitrite-free con
Product type
Maximum secondary amine content: 0.5%

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

VietnamRestrictedAnnex ACD Annex VI (Preservatives) #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt (+) 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon / piroctone Olamine
CAS
50650-76-5
Max concentration
1% 0.5%
Conditions of use
Rinse-off products For other products

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

PhilippinesRestrictedAnnex ACD Annex III (Restricted) #61
Chemical name
monoalkanolamines Monoalkylamines, and their salts
Max concentration
• Do not use with nitrosating systems • Minimum purity: 99% • Maximum secondary amine content : 0.5% (applies to raw materials) • Maximum nitrosamine content: 50  g/kg (21) • Keep in nitrite-free con
Product type
Maximum secondary amine content: 0.5%

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

PhilippinesRestrictedAnnex ACD Annex VI (Preservatives) #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt (+) 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon / piroctone Olamine
CAS
50650-76-5
Max concentration
1% 0.5%
Conditions of use
Rinse-off products For other products

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

GCC12 regulations
UAERestrictedAnnex III #61
Chemical name
Monoalkylamines, monoalkanolamines and their salts
CAS
68890-66-4
Max concentration
Maximum secondary amine content: 0.5%
Other conditions
- Do not use with nitrosating systems - Minimum purity: 99% - Maximum secondary amine content: 0.5% (applies to raw materials) - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers

Source: GSO 1943:2024 (based on EU 1223/2009 III)

UAERestrictedAnnex V #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt
CAS
50650-76-5 / 68890-66-4
Max concentration
a) 1.0% b) 0.5%
Product type
a) Rinse-off products b) Other products

Source: GSO 1943:2024 (based on EU 1223/2009 V)

Saudi ArabiaRestrictedAnnex III #61
Chemical name
Monoalkylamines, monoalkanolamines and their salts
CAS
68890-66-4
Max concentration
Maximum secondary amine content: 0.5%
Other conditions
- Do not use with nitrosating systems - Minimum purity: 99% - Maximum secondary amine content: 0.5% (applies to raw materials) - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers

Source: GSO 1943:2024 (based on EU 1223/2009 III)

Saudi ArabiaRestrictedAnnex V #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt
CAS
50650-76-5 / 68890-66-4
Max concentration
a) 1.0% b) 0.5%
Product type
a) Rinse-off products b) Other products

Source: GSO 1943:2024 (based on EU 1223/2009 V)

QatarRestrictedAnnex III #61
Chemical name
Monoalkylamines, monoalkanolamines and their salts
CAS
68890-66-4
Max concentration
Maximum secondary amine content: 0.5%
Other conditions
- Do not use with nitrosating systems - Minimum purity: 99% - Maximum secondary amine content: 0.5% (applies to raw materials) - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers

Source: GSO 1943:2024 (based on EU 1223/2009 III)

QatarRestrictedAnnex V #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt
CAS
50650-76-5 / 68890-66-4
Max concentration
a) 1.0% b) 0.5%
Product type
a) Rinse-off products b) Other products

Source: GSO 1943:2024 (based on EU 1223/2009 V)

OmanRestrictedAnnex III #61
Chemical name
Monoalkylamines, monoalkanolamines and their salts
CAS
68890-66-4
Max concentration
Maximum secondary amine content: 0.5%
Other conditions
- Do not use with nitrosating systems - Minimum purity: 99% - Maximum secondary amine content: 0.5% (applies to raw materials) - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers

Source: GSO 1943:2024 (based on EU 1223/2009 III)

OmanRestrictedAnnex V #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt
CAS
50650-76-5 / 68890-66-4
Max concentration
a) 1.0% b) 0.5%
Product type
a) Rinse-off products b) Other products

Source: GSO 1943:2024 (based on EU 1223/2009 V)

KuwaitRestrictedAnnex III #61
Chemical name
Monoalkylamines, monoalkanolamines and their salts
CAS
68890-66-4
Max concentration
Maximum secondary amine content: 0.5%
Other conditions
- Do not use with nitrosating systems - Minimum purity: 99% - Maximum secondary amine content: 0.5% (applies to raw materials) - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers

Source: GSO 1943:2024 (based on EU 1223/2009 III)

KuwaitRestrictedAnnex V #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt
CAS
50650-76-5 / 68890-66-4
Max concentration
a) 1.0% b) 0.5%
Product type
a) Rinse-off products b) Other products

Source: GSO 1943:2024 (based on EU 1223/2009 V)

BahrainRestrictedAnnex III #61
Chemical name
Monoalkylamines, monoalkanolamines and their salts
CAS
68890-66-4
Max concentration
Maximum secondary amine content: 0.5%
Other conditions
- Do not use with nitrosating systems - Minimum purity: 99% - Maximum secondary amine content: 0.5% (applies to raw materials) - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers

Source: GSO 1943:2024 (based on EU 1223/2009 III)

BahrainRestrictedAnnex V #35
Chemical name
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt
CAS
50650-76-5 / 68890-66-4
Max concentration
a) 1.0% b) 0.5%
Product type
a) Rinse-off products b) Other products

Source: GSO 1943:2024 (based on EU 1223/2009 V)

EAEUNo restrictions

No specific restrictions for PIROCTONE OLAMINE in Russia, Belarus, Kazakhstan, Armenia, Kyrgyzstan.

Frequently Asked Questions

Is PIROCTONE OLAMINE banned in any country?

PIROCTONE OLAMINE is not banned in any of the 26 markets tracked by Formpli. However, it may be subject to restrictions or conditions of use in some markets.

What are the restrictions on PIROCTONE OLAMINE in cosmetics?

PIROCTONE OLAMINE is restricted or has conditions of use in UAE, Bahrain, Brazil, European Union, Indonesia, Japan, South Korea, Kuwait, Malaysia, Oman, Philippines, Qatar, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Restrictions may include maximum concentration limits, product type limitations, or mandatory labeling requirements. See the detailed regulations above for specifics.

Can I use PIROCTONE OLAMINE in cosmetics?

PIROCTONE OLAMINE is regulated in 18 markets. It has restrictions in UAE, Bahrain, Brazil, European Union, Indonesia, Japan, South Korea, Kuwait, Malaysia, Oman, Philippines, Qatar, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Use Formpli's free screening tool to check your full ingredient list against all 26 markets at once.

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This information is for reference only and does not constitute legal or regulatory advice. Regulations change — always verify with official sources and consult a regulatory specialist before exporting cosmetic products. Data sourced from EU COSING, US FDA, Health Canada, MHLW Japan, MFDS Korea, ASEAN ACD, GCC SFDA, TGA Australia, ANVISA Brazil, EAEU TR CU, and Taiwan TFDA.