METHYLISOTHIAZOLINONE

RestrictedCAS 2682-20-428 regulations across 20 markets

METHYLISOTHIAZOLINONE is a cosmetic ingredient classified as Preservative. Also known as CAS 2682-20-4. It is regulated in 20 markets including UAE, Australia, Bahrain.

Also Known As

CAS Number: 26172-55-4, 2682-20-4, 55965-84-9

Market Overview — 29 Markets

European Union2

United Kingdom2

United States

California

Maryland

Washington

Canada1

Brazil1

South Korea1

Japan1

Taiwan1

Australia1

Singapore1

Malaysia1

Thailand1

Indonesia1

Vietnam1

Philippines1

UAE2

Saudi Arabia2

Qatar2

Oman2

Kuwait2

Bahrain2

Russia

Belarus

Kazakhstan

Armenia

Kyrgyzstan

Detailed Regulations

Europe4 regulations

European UnionRestrictedAnnex V #39

Chemical name: Mixture of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one with magnesium chloride and magnesium nitrate
CAS: 26172-55-4, 2682-20-4, 55965-84-9
Max concentration: 0.0015% (of a mixture in the ratio 3:1 of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one
Product type: Rinse-off

Source: EC 1223/2009 Annex V

European UnionRestrictedAnnex V #57

Chemical name: 2-Methyl-2H-isothiazol-3-one
CAS: 2682-20-4
Max concentration: 0,0015 % Rinse-off products

Source: EC 1223/2009 Annex V

United KingdomRestrictedAnnex V #39

Chemical name: Mixture of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-methylisothiazol-3(2H)-one
CAS: 26172-55-4, 2682-20-4, 55965-84-9
Max concentration: 0,0015 % (of a mixture in the ratio 3:1 of 5-chloro-2-methylisothiazol 3(2H)-one and 2-methylisothiazol-3 (2H)-one)
Product type: Rinse-off products
Conditions of use: Max: 0,0015 % (of a mixture in the ratio 3:1 of 5-chloro-2-methylisothiazol 3(2H)-one and 2-methylisothiazol-3 (2H)-one)

Source: UK retained EC 1223/2009 Annex V

United KingdomRestrictedAnnex V #57

Chemical name: 2-Methyl-2H-isothiazol-3-one
CAS: 2682-20-4
Max concentration: 0,0015 %
Product type: Rinse-off products
Conditions of use: Max: 0,0015 %

Source: UK retained EC 1223/2009 Annex V

Americas2 regulations

CanadaRestrictedAnnex Table 2 (Restricted)

Chemical name: Methylisothiazolinone (MI)
CAS: 2682-20-4
Max concentration: b) 0.0015%
Conditions of use: a) Not permitted in leave-on products. b) Rinse-off products Note: If MI is present in a formulation with Methylisothiazolinone / Methylchloroisothiazolinone (MI/MCI) in combination, the cumulative, total concentration of MI and MI/MCI may not exceed 0.0015%.

Source: Health Canada Cosmetic Ingredient Hotlist

BrazilRestrictedAnnex RDC_528 #57

Chemical name: 2-metil-4-isotiazoli na-3-ona
CAS: 2682-20-4
Max concentration: 0,0015% em produtos que se enxáguem.

Source: ANVISA RDC 528

East Asia & Oceania4 regulations

South KoreaRestrictedAnnex restricted #M1052

Chemical name: Methylisothiazolinone
Conditions of use: * 배합한도 : ∙ 사용 후 씻어내는 제품 0.0015% (단, 메칠클로로이소치아졸리논과 메칠이소치아졸리논 혼합물과 병행 사용 금지) ∙ 기타 제품에는 사용금지

Source: MFDS Korea Cosmetics Regulation

JapanRestrictedAnnex Appendix 3 (Preservatives) #3-2

Chemical name: Methyl isothiazolinone
Max concentration: 0.01%
Product type: Rinse-off (cosmetics washed away after use)

Source: MHLW Standards for Cosmetics (Notification No.331 of 2000)

TaiwanRestrictedAnnex Preservatives List #29

Chemical name: 2-Methyl-2H-isothiazol-3-one
CAS: 2682-20-4
Max concentration: 0.0015 %
Product type: Rinse off products

Source: TFDA Cosmetics Regulations

AustraliaRestrictedAnnex Schedule 6 (Poison) #SUSMP Schedule 6

Chemical name: METHYLISOTHIAZOLINONE except
Conditions of use: (a) in rinse-off cosmetic preparations or therapeutic goods intended for topical rinse-off application containing 0.0015% or less of methylisothiazolinone; or (b) in other preparations that are not intended for direct application to the skin containing 0.1% or less of methylisothiazolinone

Source: TGA SUSMP F2026L00060

ASEAN6 regulations

SingaporeRestrictedAnnex ACD Annex VI (Preservatives) #57

Chemical name: 2-Methyl-2H-isothiazol-3-one (INCI) / Methylisothiazolinone (14)
CAS: 2682-20-4
Max concentration: 0.0015%
Conditions of use: Rinse-off products only

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

MalaysiaRestrictedAnnex ACD Annex VI (Preservatives) #57

Chemical name: 2-Methyl-2H-isothiazol-3-one (INCI) / Methylisothiazolinone (14)
CAS: 2682-20-4
Max concentration: 0.0015%
Conditions of use: Rinse-off products only

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

ThailandRestrictedAnnex ACD Annex VI (Preservatives) #57

Chemical name: 2-Methyl-2H-isothiazol-3-one (INCI) / Methylisothiazolinone (14)
CAS: 2682-20-4
Max concentration: 0.0015%
Conditions of use: Rinse-off products only

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

IndonesiaRestrictedAnnex ACD Annex VI (Preservatives) #57

Chemical name: 2-Methyl-2H-isothiazol-3-one (INCI) / Methylisothiazolinone (14)
CAS: 2682-20-4
Max concentration: 0.0015%
Conditions of use: Rinse-off products only

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

VietnamRestrictedAnnex ACD Annex VI (Preservatives) #57

Chemical name: 2-Methyl-2H-isothiazol-3-one (INCI) / Methylisothiazolinone (14)
CAS: 2682-20-4
Max concentration: 0.0015%
Conditions of use: Rinse-off products only

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

PhilippinesRestrictedAnnex ACD Annex VI (Preservatives) #57

Chemical name: 2-Methyl-2H-isothiazol-3-one (INCI) / Methylisothiazolinone (14)
CAS: 2682-20-4
Max concentration: 0.0015%
Conditions of use: Rinse-off products only

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

GCC12 regulations

UAERestrictedAnnex V #39

Chemical name: Mixture of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one with magnesium chloride and magnesium nitrate
CAS: 26172-55-4, 2682-20-4, 55965-84-9
Max concentration: 0.0015% (of a mixture in the ratio 3:1 of 5-Chloro-2-methyl-isothiazol-3(2H)-one and 2-Methylisothiazol-3(2H)-one
Product type: Rinse-off