METHOTREXATE

BannedCAS 59-05-223 regulations across 23 markets

METHOTREXATE is a cosmetic ingredient classified as Not Reported. Also known as CAS 59-05-2. It is regulated in 23 markets including UAE, Armenia, Bahrain.

Also Known As

CAS Number
59-05-2

Market Overview — 29 Markets

European Union1
United Kingdom1
United States
California1
Maryland
Washington
Canada1
Brazil
South Korea1
Japan
Taiwan1
Australia
Singapore1
Malaysia1
Thailand1
Indonesia1
Vietnam1
Philippines1
UAE1
Saudi Arabia1
Qatar1
Oman1
Kuwait1
Bahrain1
Russia1
Belarus1
Kazakhstan1
Armenia1
Kyrgyzstan1

Detailed Regulations

Europe2 regulations
European UnionBannedAnnex II #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: EC 1223/2009 Annex II

United KingdomBannedAnnex II #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: UK retained EC 1223/2009 Annex II

Americas2 regulations
CaliforniaRestrictedAnnex PROP65
Chemical name
Methotrexate
CAS
59-05-2
Conditions of use
Warning required under California Proposition 65

Source: California Prop 65 (OEHHA)

CanadaBannedAnnex Table 1 (Prohibited)
Chemical name
Methotrexate
CAS
59-05-2
Conditions of use
Prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

East Asia & Oceania2 regulations
South KoreaBannedAnnex banned #M18
Chemical name
Methotrexate

Source: MFDS Korea Cosmetics Regulation

TaiwanBannedAnnex Prohibited Ingredients List #405
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: TFDA Cosmetics Regulations

ASEAN6 regulations
SingaporeBannedAnnex ACD Annex II (Prohibited) #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

MalaysiaBannedAnnex ACD Annex II (Prohibited) #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

ThailandBannedAnnex ACD Annex II (Prohibited) #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

IndonesiaBannedAnnex ACD Annex II (Prohibited) #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

VietnamBannedAnnex ACD Annex II (Prohibited) #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

PhilippinesBannedAnnex ACD Annex II (Prohibited) #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

GCC6 regulations
UAEBannedAnnex II #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: GSO 1943:2024 (based on EU 1223/2009 II)

Saudi ArabiaBannedAnnex II #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: GSO 1943:2024 (based on EU 1223/2009 II)

QatarBannedAnnex II #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: GSO 1943:2024 (based on EU 1223/2009 II)

OmanBannedAnnex II #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: GSO 1943:2024 (based on EU 1223/2009 II)

KuwaitBannedAnnex II #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: GSO 1943:2024 (based on EU 1223/2009 II)

BahrainBannedAnnex II #6
Chemical name
Methotrexate (INN)
CAS
59-05-2

Source: GSO 1943:2024 (based on EU 1223/2009 II)

EAEU5 regulations
RussiaBannedAnnex 1 #6
Chemical name
Метотрексат (INN)
CAS
59-05-2

Source: TR CU 009/2011 Annex 1 (Prohibited Substances) (Ref 6)

BelarusBannedAnnex 1 #6
Chemical name
Метотрексат (INN)
CAS
59-05-2

Source: TR CU 009/2011 Annex 1 (Prohibited Substances) (Ref 6)

KazakhstanBannedAnnex 1 #6
Chemical name
Метотрексат (INN)
CAS
59-05-2

Source: TR CU 009/2011 Annex 1 (Prohibited Substances) (Ref 6)

ArmeniaBannedAnnex 1 #6
Chemical name
Метотрексат (INN)
CAS
59-05-2

Source: TR CU 009/2011 Annex 1 (Prohibited Substances) (Ref 6)

KyrgyzstanBannedAnnex 1 #6
Chemical name
Метотрексат (INN)
CAS
59-05-2

Source: TR CU 009/2011 Annex 1 (Prohibited Substances) (Ref 6)

Frequently Asked Questions

Is METHOTREXATE banned in any country?

Yes, METHOTREXATE is banned in UAE, Armenia, Bahrain, Belarus, Canada, European Union, Indonesia, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Always check current regulations before formulating products for these markets.

What are the restrictions on METHOTREXATE in cosmetics?

METHOTREXATE is banned in UAE, Armenia, Bahrain, Belarus, Canada, European Union, Indonesia, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam and has no specific restrictions in other tracked markets.

Can I use METHOTREXATE in cosmetics?

METHOTREXATE is regulated in 23 markets. It is banned in UAE, Armenia, Bahrain, Belarus, Canada, European Union, Indonesia, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Use Formpli's free screening tool to check your full ingredient list against all 26 markets at once.

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This information is for reference only and does not constitute legal or regulatory advice. Regulations change — always verify with official sources and consult a regulatory specialist before exporting cosmetic products. Data sourced from EU COSING, US FDA, Health Canada, MHLW Japan, MFDS Korea, ASEAN ACD, GCC SFDA, TGA Australia, ANVISA Brazil, EAEU TR CU, and Taiwan TFDA.