HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL

RestrictedCAS 128729-28-216 regulations across 16 markets

HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL is a cosmetic ingredient classified as Hair Dyeing. Also known as CAS 128729-28-2. It is regulated in 16 markets including UAE, Bahrain, European Union.

Also Known As

CAS Number: 128729-28-2

Market Overview — 29 Markets

European Union1

United Kingdom1

United States

California

Maryland

Washington

Canada

Brazil

South Korea1

Japan

Taiwan1

Australia

Singapore1

Malaysia1

Thailand1

Indonesia1

Vietnam1

Philippines1

UAE1

Saudi Arabia1

Qatar1

Oman1

Kuwait1

Bahrain1

Russia

Belarus

Kazakhstan

Armenia

Kyrgyzstan

Detailed Regulations

Europe2 regulations

European UnionRestrictedAnnex III #239

Chemical name: Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) and its tetrahydro-chloride
CAS: 128729-30-6 -- 128729-28-2
Product type: Hair dye substance in oxidative hair dye products
Conditions of use: Hair colourants can cause severe allergic reactions Read and follow instructions
Other conditions: After mixing under oxidative conditions the maximumconcentration applied to hair must not exceed 0.4% (as tetrahydro-chloride)

Source: EC 1223/2009 Annex III

United KingdomRestrictedAnnex III #239

Chemical name: Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) and its tetrahydro-chloride
CAS: 128729-30-6 / 128729-28-2
Product type: Hair dye substance in oxidative hair dye products
Conditions of use: To be printed on the label: The mixing ratio. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “ black henna ” tattoos may increase your risk of allergy. Do not colour your hair if: you have a rash on your face or sensitive, irritated and damaged scalp, you have ever experienced any reaction after colouring your hair, you have experienced a reaction to a temporary “ black henna ” tattoo in the past. Hair colourants can cause severe allergic reactions.
Other conditions: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,4 % (as tetrahydrochloride)

Source: UK retained EC 1223/2009 Annex III

AmericasNo restrictions

No specific restrictions for HYDROXYPROPYL BIS(N-HYDROXYETHYL-P-PHENYLENEDIAMINE) HCL in United States, California, Maryland, Washington, Canada, Brazil.

East Asia & Oceania2 regulations

South KoreaRestrictedAnnex restricted #M692

Chemical name: Hydroxypropyl bis(N-Hydroxyethyl-p-Phenylenediamine) HCl
Conditions of use: * 배합한도 : ∙ 산화염모에 0.4% ∙ 기타 제품에는 사용금지

Source: MFDS Korea Cosmetics Regulation

TaiwanRestrictedAnnex Restricted Ingredients List #109

Chemical name: Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine)and its tetrahydrochloride
CAS: 128729-30-6/ 128729-28-2
Max concentration: 0.4% (以tetrahydrochloride計)
Product type: Oxidative hair dye products

Source: TFDA Cosmetics Regulations

ASEAN6 regulations

SingaporeRestrictedAnnex ACD Annex III (Restricted) #242

Chemical name: Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) and its tetrahydrochloride Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) HCl
CAS: 128729-30-6 / 128729-28-2
Max concentration: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.4 %(as tetrahydrochloride) The direction for use 'wear suitable gloves' must be included in label or
Product type: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past Do not use to dye eyelashes or eyebrows

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

MalaysiaRestrictedAnnex ACD Annex III (Restricted) #242

Chemical name: Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) and its tetrahydrochloride Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) HCl
CAS: 128729-30-6 / 128729-28-2
Max concentration: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.4 %(as tetrahydrochloride) The direction for use 'wear suitable gloves' must be included in label or
Product type: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past Do not use to dye eyelashes or eyebrows

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

ThailandRestrictedAnnex ACD Annex III (Restricted) #242

Chemical name: Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) and its tetrahydrochloride Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) HCl
CAS: 128729-30-6 / 128729-28-2
Max concentration: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.4 %(as tetrahydrochloride) The direction for use 'wear suitable gloves' must be included in label or
Product type: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past Do not use to dye eyelashes or eyebrows

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

IndonesiaRestrictedAnnex ACD Annex III (Restricted) #242

Chemical name: Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) and its tetrahydrochloride Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) HCl
CAS: 128729-30-6 / 128729-28-2
Max concentration: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.4 %(as tetrahydrochloride) The direction for use 'wear suitable gloves' must be included in label or
Product type: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past Do not use to dye eyelashes or eyebrows

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

VietnamRestrictedAnnex ACD Annex III (Restricted) #242

Chemical name: Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) and its tetrahydrochloride Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) HCl
CAS: 128729-30-6 / 128729-28-2
Max concentration: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.4 %(as tetrahydrochloride) The direction for use 'wear suitable gloves' must be included in label or
Product type: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past Do not use to dye eyelashes or eyebrows

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

PhilippinesRestrictedAnnex ACD Annex III (Restricted) #242

Chemical name: Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) and its tetrahydrochloride Hydroxypropyl bis(N-hydroxyethyl-p- phenylenediamine) HCl
CAS: 128729-30-6 / 128729-28-2
Max concentration: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.4 %(as tetrahydrochloride) The direction for use 'wear suitable gloves' must be included in label or
Product type: Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past Do not use to dye eyelashes or eyebrows

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

GCC6 regulations

UAERestrictedAnnex III #239

Chemical name: Hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) and its tetrahydro-chloride
CAS: 128729-30-6 -- 128729-28-2
Product type: Hair dye substance in oxidative hair dye products
Conditions of use: Hair colourants can cause severe allergic reactions Read and follow instructions
Other conditions: After mixing under oxidative conditions the maximumconcentration applied to hair must not exceed 0.4% (as tetrahydro-chloride)