ESTRADIOL

BannedCAS 50-28-211 regulations across 11 markets

ESTRADIOL is a cosmetic ingredient classified as Skin Conditioning. Also known as CAS 50-28-2. It is regulated in 11 markets including UAE, Bahrain, Canada.

Also Known As

CAS Number
50-28-2

Market Overview — 29 Markets

European Union1
United Kingdom
United States
California1
Maryland
Washington
Canada1
Brazil
South Korea1
Japan
Taiwan1
Australia
Singapore
Malaysia
Thailand
Indonesia
Vietnam
Philippines
UAE1
Saudi Arabia1
Qatar1
Oman1
Kuwait1
Bahrain1
Russia
Belarus
Kazakhstan
Armenia
Kyrgyzstan

Detailed Regulations

Europe1 regulation
European UnionBannedAnnex II #260
Chemical name
Oestrogens
CAS
50-28-2

Source: EC 1223/2009 Annex II

Americas2 regulations
CaliforniaRestrictedAnnex PROP65
Chemical name
Estradiol 17B
CAS
50-28-2
Conditions of use
Warning required under California Proposition 65

Source: California Prop 65 (OEHHA)

CanadaBannedAnnex Table 1 (Prohibited)
Chemical name
Estradiol
CAS
50-28-2
Conditions of use
Prohibited in cosmetics

Source: Health Canada Cosmetic Ingredient Hotlist

East Asia & Oceania2 regulations
South KoreaBannedAnnex banned #M52
Chemical name
Estradiol

Source: MFDS Korea Cosmetics Regulation

TaiwanBannedAnnex Prohibited Ingredients List #305
Chemical name
Estradiol
CAS
50-28-2

Source: TFDA Cosmetics Regulations

ASEANNo restrictions

No specific restrictions for ESTRADIOL in Singapore, Malaysia, Thailand, Indonesia, Vietnam, Philippines.

GCC6 regulations
UAEBannedAnnex II #260
Chemical name
Oestrogens
CAS
50-28-2

Source: GSO 1943:2024 (based on EU 1223/2009 II)

Saudi ArabiaBannedAnnex II #260
Chemical name
Oestrogens
CAS
50-28-2

Source: GSO 1943:2024 (based on EU 1223/2009 II)

QatarBannedAnnex II #260
Chemical name
Oestrogens
CAS
50-28-2

Source: GSO 1943:2024 (based on EU 1223/2009 II)

OmanBannedAnnex II #260
Chemical name
Oestrogens
CAS
50-28-2

Source: GSO 1943:2024 (based on EU 1223/2009 II)

KuwaitBannedAnnex II #260
Chemical name
Oestrogens
CAS
50-28-2

Source: GSO 1943:2024 (based on EU 1223/2009 II)

BahrainBannedAnnex II #260
Chemical name
Oestrogens
CAS
50-28-2

Source: GSO 1943:2024 (based on EU 1223/2009 II)

EAEUNo restrictions

No specific restrictions for ESTRADIOL in Russia, Belarus, Kazakhstan, Armenia, Kyrgyzstan.

Frequently Asked Questions

Is ESTRADIOL banned in any country?

Yes, ESTRADIOL is banned in UAE, Bahrain, Canada, European Union, South Korea, Kuwait, Oman, Qatar, Saudi Arabia, Taiwan. Always check current regulations before formulating products for these markets.

What are the restrictions on ESTRADIOL in cosmetics?

ESTRADIOL is banned in UAE, Bahrain, Canada, European Union, South Korea, Kuwait, Oman, Qatar, Saudi Arabia, Taiwan and has no specific restrictions in other tracked markets.

Can I use ESTRADIOL in cosmetics?

ESTRADIOL is regulated in 11 markets. It is banned in UAE, Bahrain, Canada, European Union, South Korea, Kuwait, Oman, Qatar, Saudi Arabia, Taiwan. Use Formpli's free screening tool to check your full ingredient list against all 26 markets at once.

Screen ESTRADIOL with your full formula

Paste your entire ingredient list and get a compliance report across 26 markets — free, no signup.

Check Ingredients Free

This information is for reference only and does not constitute legal or regulatory advice. Regulations change — always verify with official sources and consult a regulatory specialist before exporting cosmetic products. Data sourced from EU COSING, US FDA, Health Canada, MHLW Japan, MFDS Korea, ASEAN ACD, GCC SFDA, TGA Australia, ANVISA Brazil, EAEU TR CU, and Taiwan TFDA.