DIHYDROXYINDOLINE
DIHYDROXYINDOLINE is a cosmetic ingredient classified as Hair Dyeing. Also known as CAS 29539-03-5. It is regulated in 16 markets including UAE, Bahrain, European Union.
Also Known As
- CAS Number
- 29539-03-5
Market Overview — 29 Markets
Detailed Regulations
Europe2 regulations
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt (see note 17).
- CAS
- 29539-03-5 - 138937-28-7
- Max concentration
- 2.0%
- Product type
- Hair dye substance in non-oxidative hair dye products
- Conditions of use
- - Can cause allergic reaction - You have ever experienced any reaction afther colouring your hair - You have experienced a reaction to a temporary 'black henna' tattoo in the past
Source: EC 1223/2009 Annex III
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt
- CAS
- 29539-03-5 / 138937-28-7
- Max concentration
- 2,0 %
- Product type
- Hair dye substance in non-oxidative hair dye products
- Conditions of use
- Max: 2,0 % Can cause allergic reaction
Source: UK retained EC 1223/2009 Annex III
AmericasNo restrictions
No specific restrictions for DIHYDROXYINDOLINE in United States, California, Maryland, Washington, Canada, Brazil.
East Asia & Oceania2 regulations
- Chemical name
- Dihydroxyindoline
Source: MFDS Korea Cosmetics Regulation
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt
- CAS
- 29539-03-5/ 138937-28-7
- Max concentration
- 2%
- Product type
- Non-oxidative hair dye products
Source: TFDA Cosmetics Regulations
ASEAN6 regulations
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt Dihydroxyindoline / Dihydroxyindoline HBr
- CAS
- 29539-03-5
- Max concentration
- 2.0%
- Product type
- Hair dye substance in non- oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Conditions of use
- The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: Can cause allergic reaction Do not use to dye eyelashes or eyebrows
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt Dihydroxyindoline / Dihydroxyindoline HBr
- CAS
- 29539-03-5
- Max concentration
- 2.0%
- Product type
- Hair dye substance in non- oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Conditions of use
- The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: Can cause allergic reaction Do not use to dye eyelashes or eyebrows
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt Dihydroxyindoline / Dihydroxyindoline HBr
- CAS
- 29539-03-5
- Max concentration
- 2.0%
- Product type
- Hair dye substance in non- oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Conditions of use
- The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: Can cause allergic reaction Do not use to dye eyelashes or eyebrows
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt Dihydroxyindoline / Dihydroxyindoline HBr
- CAS
- 29539-03-5
- Max concentration
- 2.0%
- Product type
- Hair dye substance in non- oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Conditions of use
- The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: Can cause allergic reaction Do not use to dye eyelashes or eyebrows
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt Dihydroxyindoline / Dihydroxyindoline HBr
- CAS
- 29539-03-5
- Max concentration
- 2.0%
- Product type
- Hair dye substance in non- oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Conditions of use
- The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: Can cause allergic reaction Do not use to dye eyelashes or eyebrows
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt Dihydroxyindoline / Dihydroxyindoline HBr
- CAS
- 29539-03-5
- Max concentration
- 2.0%
- Product type
- Hair dye substance in non- oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
- Conditions of use
- The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: Can cause allergic reaction Do not use to dye eyelashes or eyebrows
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
GCC6 regulations
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt (see note 17).
- CAS
- 29539-03-5 - 138937-28-7
- Max concentration
- 2.0%
- Product type
- Hair dye substance in non-oxidative hair dye products
- Conditions of use
- - Can cause allergic reaction - You have ever experienced any reaction afther colouring your hair - You have experienced a reaction to a temporary 'black henna' tattoo in the past
Source: GSO 1943:2024 (based on EU 1223/2009 III)
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt (see note 17).
- CAS
- 29539-03-5 - 138937-28-7
- Max concentration
- 2.0%
- Product type
- Hair dye substance in non-oxidative hair dye products
- Conditions of use
- - Can cause allergic reaction - You have ever experienced any reaction afther colouring your hair - You have experienced a reaction to a temporary 'black henna' tattoo in the past
Source: GSO 1943:2024 (based on EU 1223/2009 III)
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt (see note 17).
- CAS
- 29539-03-5 - 138937-28-7
- Max concentration
- 2.0%
- Product type
- Hair dye substance in non-oxidative hair dye products
- Conditions of use
- - Can cause allergic reaction - You have ever experienced any reaction afther colouring your hair - You have experienced a reaction to a temporary 'black henna' tattoo in the past
Source: GSO 1943:2024 (based on EU 1223/2009 III)
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt (see note 17).
- CAS
- 29539-03-5 - 138937-28-7
- Max concentration
- 2.0%
- Product type
- Hair dye substance in non-oxidative hair dye products
- Conditions of use
- - Can cause allergic reaction - You have ever experienced any reaction afther colouring your hair - You have experienced a reaction to a temporary 'black henna' tattoo in the past
Source: GSO 1943:2024 (based on EU 1223/2009 III)
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt (see note 17).
- CAS
- 29539-03-5 - 138937-28-7
- Max concentration
- 2.0%
- Product type
- Hair dye substance in non-oxidative hair dye products
- Conditions of use
- - Can cause allergic reaction - You have ever experienced any reaction afther colouring your hair - You have experienced a reaction to a temporary 'black henna' tattoo in the past
Source: GSO 1943:2024 (based on EU 1223/2009 III)
- Chemical name
- 2,3-Dihydro-1H-indole-5,6-diol and its hydrobromide salt (see note 17).
- CAS
- 29539-03-5 - 138937-28-7
- Max concentration
- 2.0%
- Product type
- Hair dye substance in non-oxidative hair dye products
- Conditions of use
- - Can cause allergic reaction - You have ever experienced any reaction afther colouring your hair - You have experienced a reaction to a temporary 'black henna' tattoo in the past
Source: GSO 1943:2024 (based on EU 1223/2009 III)
EAEUNo restrictions
No specific restrictions for DIHYDROXYINDOLINE in Russia, Belarus, Kazakhstan, Armenia, Kyrgyzstan.
Frequently Asked Questions
Is DIHYDROXYINDOLINE banned in any country?
DIHYDROXYINDOLINE is not banned in any of the 26 markets tracked by Formpli. However, it may be subject to restrictions or conditions of use in some markets.
What are the restrictions on DIHYDROXYINDOLINE in cosmetics?
DIHYDROXYINDOLINE is restricted or has conditions of use in UAE, Bahrain, European Union, Indonesia, South Korea, Kuwait, Malaysia, Oman, Philippines, Qatar, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Restrictions may include maximum concentration limits, product type limitations, or mandatory labeling requirements. See the detailed regulations above for specifics.
Can I use DIHYDROXYINDOLINE in cosmetics?
DIHYDROXYINDOLINE is regulated in 16 markets. It has restrictions in UAE, Bahrain, European Union, Indonesia, South Korea, Kuwait, Malaysia, Oman, Philippines, Qatar, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Use Formpli's free screening tool to check your full ingredient list against all 26 markets at once.
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Check Ingredients FreeThis information is for reference only and does not constitute legal or regulatory advice. Regulations change — always verify with official sources and consult a regulatory specialist before exporting cosmetic products. Data sourced from EU COSING, US FDA, Health Canada, MHLW Japan, MFDS Korea, ASEAN ACD, GCC SFDA, TGA Australia, ANVISA Brazil, EAEU TR CU, and Taiwan TFDA.