CI 45410
RestrictedCAS 18472-87-231 regulations across 22 markets
CI 45410 is a cosmetic ingredient classified as Colorant. Also known as Red No. 27, CAS 18472-87-2. It is regulated in 22 markets including UAE, Armenia, Bahrain.
Also Known As
- Common names
- Red No. 27, RED 28 LAKE, RED 27 LAKE, Red No. 28
- CAS Number
- 13473-26-2, 18472-87-2
- INCI variants
- RED 27, RED 28
Market Overview — 29 Markets
European Union2
United Kingdom3
United States
California
Maryland
Washington
Canada
Brazil1
South Korea1
Japan
Taiwan1
Australia
Singapore1
Malaysia1
Thailand1
Indonesia1
Vietnam1
Philippines1
UAE2
Saudi Arabia2
Qatar2
Oman2
Kuwait2
Bahrain2
Russia1
Belarus1
Kazakhstan1
Armenia1
Kyrgyzstan1
Detailed Regulations
Europe5 regulations
European UnionRestricted
- Chemical name
- Fluorescein, 2',4',5',7'-tetrabromo-4,5,6,7- tetrachloro-, disodium salt (CI 45410)
- CAS
- 18472-87-2
- Max concentration
- (b) 0,4 %
- Product type
- (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products
- Conditions of use
- (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.”
- Other conditions
- (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0 %
Source: EC 1223/2009 Annex III
European UnionRestricted
- Chemical name
- 3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 18472-87-2
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45410
Source: EC 1223/2009 Annex IV
United KingdomRestricted
- Chemical name
- Fluorescein, 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-, disodium salt (CI 45410)
- CAS
- 18472-87-2
- Product type
- (a) Hair dye substance in oxidative hair dye products
- Conditions of use
- (a) To be printed on the label: The mixing ratio. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “ black henna ” tattoos may increase your risk of allergy. Do not colour your hair if: you have a rash on your face or sensitive, irritated and damaged scalp, you have ever experienced any reaction after colouring your hair, you have experienced a reaction to a temporary “ black henna ” tattoo in the past. Hair colorants can cause severe allergic reactions.
- Other conditions
- (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0 %
Source: UK retained EC 1223/2009 Annex III
United KingdomRestricted
- Chemical name
- Fluorescein, 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-, disodium salt (CI 45410)
- CAS
- 18472-87-2
- Max concentration
- (b) 0,4 %
- Product type
- (b) Hair dye substance in non-oxidative hair dye products
- Conditions of use
- Max: (b) 0,4 %
Source: UK retained EC 1223/2009 Annex III
United KingdomRestricted
- Chemical name
- 3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- Not more than 1 % 2-(6-hydroxy-3-oxo-3Η xanthen-9-yl) benzoic acid and 2 % 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl) benzoic acid
- Color Index
- 45410
Source: UK retained EC 1223/2009 Annex IV
Americas1 regulation
BrazilRestricted
- Product type
- products_in_general
- Conditions of use
- Application fields: products_in_general | Limitations: Não mais que 1% de ácido 2- (6-hidróxi-3-oxo-3H-xantin-9- il) benzóico (fluoresceína) e 2% de ácido 2-(bromo-6- hidróxi-3-oxo-3H-xantin-9-il) benzóico (monobromofluoresceína)
- Color Index
- CI 45410
Source: ANVISA RDC 628
East Asia & Oceania2 regulations
South KoreaRestricted
- Chemical name
- Phloxine BK, Aka231, CI 45410
- Conditions of use
- * 배합한도 : 눈 주위에 사용할 수 없음
Source: MFDS Korea Cosmetics Regulation
TaiwanRestricted
- Chemical name
- CI 45410
- Product type
- Scope 1: All cosmetic products
- Color Index
- CI 45410
Source: TFDA Cosmetics Regulations
ASEAN6 regulations
SingaporeRestricted
- Chemical name
- Red
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45410 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
MalaysiaRestricted
- Chemical name
- Red
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45410 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
ThailandRestricted
- Chemical name
- Red
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45410 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
IndonesiaRestricted
- Chemical name
- Red
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45410 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
VietnamRestricted
- Chemical name
- Red
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45410 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
PhilippinesRestricted
- Chemical name
- Red
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45410 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
GCC12 regulations
UAERestricted
- Chemical name
- Fluorescein, 2',4',5',7'-tetrabromo-4,5,6,7- tetrachloro-, disodium salt (CI 45410)
- CAS
- 18472-87-2
- Max concentration
- (b) 0,4 %
- Product type
- (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products
- Conditions of use
- (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.”
- Other conditions
- (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0 %
Source: GSO 1943:2024 (based on EU 1223/2009 III)
UAERestricted
- Chemical name
- 3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 18472-87-2
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45410
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
Saudi ArabiaRestricted
- Chemical name
- Fluorescein, 2',4',5',7'-tetrabromo-4,5,6,7- tetrachloro-, disodium salt (CI 45410)
- CAS
- 18472-87-2
- Max concentration
- (b) 0,4 %
- Product type
- (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products
- Conditions of use
- (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.”
- Other conditions
- (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0 %
Source: GSO 1943:2024 (based on EU 1223/2009 III)
Saudi ArabiaRestricted
- Chemical name
- 3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 18472-87-2
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45410
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
QatarRestricted
- Chemical name
- Fluorescein, 2',4',5',7'-tetrabromo-4,5,6,7- tetrachloro-, disodium salt (CI 45410)
- CAS
- 18472-87-2
- Max concentration
- (b) 0,4 %
- Product type
- (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products
- Conditions of use
- (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.”
- Other conditions
- (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0 %
Source: GSO 1943:2024 (based on EU 1223/2009 III)
QatarRestricted
- Chemical name
- 3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 18472-87-2
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45410
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
OmanRestricted
- Chemical name
- Fluorescein, 2',4',5',7'-tetrabromo-4,5,6,7- tetrachloro-, disodium salt (CI 45410)
- CAS
- 18472-87-2
- Max concentration
- (b) 0,4 %
- Product type
- (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products
- Conditions of use
- (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.”
- Other conditions
- (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0 %
Source: GSO 1943:2024 (based on EU 1223/2009 III)
OmanRestricted
- Chemical name
- 3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 18472-87-2
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45410
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
KuwaitRestricted
- Chemical name
- Fluorescein, 2',4',5',7'-tetrabromo-4,5,6,7- tetrachloro-, disodium salt (CI 45410)
- CAS
- 18472-87-2
- Max concentration
- (b) 0,4 %
- Product type
- (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products
- Conditions of use
- (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.”
- Other conditions
- (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0 %
Source: GSO 1943:2024 (based on EU 1223/2009 III)
KuwaitRestricted
- Chemical name
- 3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 18472-87-2
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45410
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
BahrainRestricted
- Chemical name
- Fluorescein, 2',4',5',7'-tetrabromo-4,5,6,7- tetrachloro-, disodium salt (CI 45410)
- CAS
- 18472-87-2
- Max concentration
- (b) 0,4 %
- Product type
- (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products
- Conditions of use
- (a) To be printed on the label: The mixing ratio. “ Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, — you have experienced a reaction to a temporary ‘black henna’ tattoo in the past.”
- Other conditions
- (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 2,0 %
Source: GSO 1943:2024 (based on EU 1223/2009 III)
BahrainRestricted
- Chemical name
- 3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 18472-87-2
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45410
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
EAEU5 regulations
RussiaRestricted
- Chemical name
- 3,4,5,6-тетрахлор-2-(1,4,5,8-тетрабром-6-гидрокси-3-оксоксантен-9-ил)бензойной кислоты его нерастворимые бария, стронция и циркония лаки, соли и пигменты. 3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил)бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45410
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 79)
BelarusRestricted
- Chemical name
- 3,4,5,6-тетрахлор-2-(1,4,5,8-тетрабром-6-гидрокси-3-оксоксантен-9-ил)бензойной кислоты его нерастворимые бария, стронция и циркония лаки, соли и пигменты. 3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил)бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45410
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 79)
KazakhstanRestricted
- Chemical name
- 3,4,5,6-тетрахлор-2-(1,4,5,8-тетрабром-6-гидрокси-3-оксоксантен-9-ил)бензойной кислоты его нерастворимые бария, стронция и циркония лаки, соли и пигменты. 3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил)бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45410
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 79)
ArmeniaRestricted
- Chemical name
- 3,4,5,6-тетрахлор-2-(1,4,5,8-тетрабром-6-гидрокси-3-оксоксантен-9-ил)бензойной кислоты его нерастворимые бария, стронция и циркония лаки, соли и пигменты. 3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил)бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45410
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 79)
KyrgyzstanRestricted
- Chemical name
- 3,4,5,6-тетрахлор-2-(1,4,5,8-тетрабром-6-гидрокси-3-оксоксантен-9-ил)бензойной кислоты его нерастворимые бария, стронция и циркония лаки, соли и пигменты. 3,4,5,6-Tetrachloro-2-(1,4,5,8-tetrabromo-6-hydroxy-3-oxoxanthen-9-yl)benzoic acid and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил)бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45410
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 79)
Frequently Asked Questions
Is CI 45410 banned in any country?
CI 45410 is not banned in any of the 26 markets tracked by Formpli. However, it may be subject to restrictions or conditions of use in some markets.
What are the restrictions on CI 45410 in cosmetics?
CI 45410 is restricted or has conditions of use in UAE, Armenia, Bahrain, Brazil, Belarus, European Union, Indonesia, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Restrictions may include maximum concentration limits, product type limitations, or mandatory labeling requirements. See the detailed regulations above for specifics.
Can I use CI 45410 in cosmetics?
CI 45410 is regulated in 22 markets. It has restrictions in UAE, Armenia, Bahrain, Brazil, Belarus, European Union, Indonesia, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Use Formpli's free screening tool to check your full ingredient list against all 26 markets at once.
Screen CI 45410 with your full formula
Paste your entire ingredient list and get a compliance report across 26 markets — free, no signup.
Check Ingredients FreeThis information is for reference only and does not constitute legal or regulatory advice. Regulations change — always verify with official sources and consult a regulatory specialist before exporting cosmetic products. Data sourced from EU COSING, US FDA, Health Canada, MHLW Japan, MFDS Korea, ASEAN ACD, GCC SFDA, TGA Australia, ANVISA Brazil, EAEU TR CU, and Taiwan TFDA.