CI 45380
CI 45380 is a cosmetic ingredient classified as Colorant. Also known as Red No. 22, CAS 17372-87-1. It is regulated in 21 markets including UAE, Armenia, Bahrain.
Also Known As
- Common names
- Red No. 22, RED 21 LAKE, RED 22 LAKE, Red No. 21
- CAS Number
- 94021-89-3, 15876-39-8, 17372-87-1, 15086-94-9, 548-26-5
- INCI variants
- RED 22, RED 21
Market Overview — 29 Markets
Detailed Regulations
Europe3 regulations
- Chemical name
- Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45380
Source: EC 1223/2009 Annex IV
- Chemical name
- 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)benzoic acid; Fluorescein, 2′,4′,5′,7′-tetrabromo-; (Solvent Red 43), its disodium salt (Acid Red 87; CI 45380) and its aluminium salt (Pigment Red 90:1 Aluminium lake) when used as a substance in hair dye products
- CAS
- 15086-94-9 / 17372-87-1 (Na) / 15876-39-8 (Al)
Source: UK retained EC 1223/2009 Annex II
- Chemical name
- Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- Not more than 1 % 2-(6-hydroxy-3-oxo-3H-xanthen-9-y1) benzoic acid and 2 % 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl) benzoic acid
- Color Index
- 45380
Source: UK retained EC 1223/2009 Annex IV
AmericasNo restrictions
No specific restrictions for CI 45380 in United States, California, Maryland, Washington, Canada, Brazil.
East Asia & Oceania2 regulations
- Chemical name
- Eosine YSK, D&C Red No. 22, Aka230(1), CI 45380
Source: MFDS Korea Cosmetics Regulation
- Chemical name
- CI 45380
- Product type
- Scope 1: All cosmetic products
- Conditions of use
- Using in hair dye products is forbidden.
- Color Index
- CI 45380
Source: TFDA Cosmetics Regulations
ASEAN12 regulations
- Chemical name
- 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)benzoic acid; Fluorescein, 2',4',5',7'-tetrabromo-; and its disodium salt and its aluminium salt
- CAS
- 15086-94- 9/17372-87- 1/15876-39-8
- Product type
- hair dye products
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- Red
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9yl) benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45380 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)benzoic acid; Fluorescein, 2',4',5',7'-tetrabromo-; and its disodium salt and its aluminium salt
- CAS
- 15086-94- 9/17372-87- 1/15876-39-8
- Product type
- hair dye products
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- Red
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9yl) benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45380 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)benzoic acid; Fluorescein, 2',4',5',7'-tetrabromo-; and its disodium salt and its aluminium salt
- CAS
- 15086-94- 9/17372-87- 1/15876-39-8
- Product type
- hair dye products
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- Red
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9yl) benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45380 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)benzoic acid; Fluorescein, 2',4',5',7'-tetrabromo-; and its disodium salt and its aluminium salt
- CAS
- 15086-94- 9/17372-87- 1/15876-39-8
- Product type
- hair dye products
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- Red
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9yl) benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45380 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)benzoic acid; Fluorescein, 2',4',5',7'-tetrabromo-; and its disodium salt and its aluminium salt
- CAS
- 15086-94- 9/17372-87- 1/15876-39-8
- Product type
- hair dye products
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- Red
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9yl) benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45380 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 2-(3,6-Dihydroxy-2,4,5,7-tetrabromoxanthen-9-yl)benzoic acid; Fluorescein, 2',4',5',7'-tetrabromo-; and its disodium salt and its aluminium salt
- CAS
- 15086-94- 9/17372-87- 1/15876-39-8
- Product type
- hair dye products
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- Red
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9yl) benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45380 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
GCC6 regulations
- Chemical name
- Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45380
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
- Chemical name
- Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45380
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
- Chemical name
- Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45380
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
- Chemical name
- Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45380
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
- Chemical name
- Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45380
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
- Chemical name
- Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 17372-87-1 / 548-26-5 / 15876-39-8 / 15086-94-9 / 94021-89-3
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45380
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
EAEU5 regulations
- Chemical name
- Динатрий 2-(2,4,5,7-тетрабром-6-оксид-3-оксоксантен-9-ил)бензоат и его нерастворимые бария, стронция и циркония лаки, соли и пигменты Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил) бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45380
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 76)
- Chemical name
- Динатрий 2-(2,4,5,7-тетрабром-6-оксид-3-оксоксантен-9-ил)бензоат и его нерастворимые бария, стронция и циркония лаки, соли и пигменты Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил) бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45380
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 76)
- Chemical name
- Динатрий 2-(2,4,5,7-тетрабром-6-оксид-3-оксоксантен-9-ил)бензоат и его нерастворимые бария, стронция и циркония лаки, соли и пигменты Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил) бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45380
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 76)
- Chemical name
- Динатрий 2-(2,4,5,7-тетрабром-6-оксид-3-оксоксантен-9-ил)бензоат и его нерастворимые бария, стронция и циркония лаки, соли и пигменты Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил) бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45380
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 76)
- Chemical name
- Динатрий 2-(2,4,5,7-тетрабром-6-оксид-3-оксоксантен-9-ил)бензоат и его нерастворимые бария, стронция и циркония лаки, соли и пигменты Disodium 2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил) бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45380
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 76)
Frequently Asked Questions
Is CI 45380 banned in any country?
Yes, CI 45380 is banned in Indonesia, Malaysia, Philippines, Singapore, Thailand, United Kingdom, Vietnam. Always check current regulations before formulating products for these markets.
What are the restrictions on CI 45380 in cosmetics?
CI 45380 is restricted or has conditions of use in UAE, Armenia, Bahrain, Belarus, European Union, Indonesia, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Restrictions may include maximum concentration limits, product type limitations, or mandatory labeling requirements. See the detailed regulations above for specifics.
Can I use CI 45380 in cosmetics?
CI 45380 is regulated in 21 markets. It is banned in Indonesia, Malaysia, Philippines, Singapore, Thailand, United Kingdom, Vietnam. It has restrictions in UAE, Armenia, Bahrain, Belarus, European Union, Indonesia, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Use Formpli's free screening tool to check your full ingredient list against all 26 markets at once.
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Check Ingredients FreeThis information is for reference only and does not constitute legal or regulatory advice. Regulations change — always verify with official sources and consult a regulatory specialist before exporting cosmetic products. Data sourced from EU COSING, US FDA, Health Canada, MHLW Japan, MFDS Korea, ASEAN ACD, GCC SFDA, TGA Australia, ANVISA Brazil, EAEU TR CU, and Taiwan TFDA.