CI 45370
CI 45370 is a cosmetic ingredient classified as Colorant. Also known as ORANGE 5 LAKE, CAS 4372-02-5. It is regulated in 21 markets including UAE, Armenia, Bahrain.
Also Known As
- Common names
- ORANGE 5 LAKE, Orange No. 5
- CAS Number
- 4372-02-5, 596-03-2
- INCI variants
- ORANGE 5, ORANGE 5 ZIRCONIUM LAKE
Market Overview — 29 Markets
Detailed Regulations
Europe3 regulations
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 596-03-2; 4372-02-5
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45370
Source: EC 1223/2009 Annex IV
- Chemical name
- 4′,5′-Dibromo-3′,6′-dihydroxyspiro[isobenzofuran-1(3H),9′-[9H]xanthene]-3-one; 4′,5′-Dibromofluorescein; (Solvent Red 72) and its disodium salt (CI 45370) when used as a substance in hair dye products
- CAS
- 596-03-2 / 4372-02-5 (Na)
Source: UK retained EC 1223/2009 Annex II
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- Not more than 1 % 2-(6-hydroxy-3-oxo-3H-xanthen-9-y1) benzoic acid and 2 % 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl) benzoic acid
- Color Index
- 45370
Source: UK retained EC 1223/2009 Annex IV
AmericasNo restrictions
No specific restrictions for CI 45370 in United States, California, Maryland, Washington, Canada, Brazil.
East Asia & Oceania2 regulations
- Chemical name
- Dibromofluorescein, D&C Orange No. 5, Daidai201, CI 45370
- Conditions of use
- * 배합한도 : 눈 주위에 사용할 수 없음
Source: MFDS Korea Cosmetics Regulation
- Chemical name
- CI 45370
- Product type
- Scope 1: All cosmetic products
- Conditions of use
- Using in hair dye products is forbidden.
- Color Index
- CI 45370
Source: TFDA Cosmetics Regulations
ASEAN12 regulations
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'- [9H]xanthene]-3-one; 4',5'-Dibromofluorescein; and its sodium salt
- CAS
- 596-03-2/4372- 02-5
- Product type
- hair dye products
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- Orange
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9-yl) benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45370 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'- [9H]xanthene]-3-one; 4',5'-Dibromofluorescein; and its sodium salt
- CAS
- 596-03-2/4372- 02-5
- Product type
- hair dye products
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- Orange
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9-yl) benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45370 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'- [9H]xanthene]-3-one; 4',5'-Dibromofluorescein; and its sodium salt
- CAS
- 596-03-2/4372- 02-5
- Product type
- hair dye products
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- Orange
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9-yl) benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45370 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'- [9H]xanthene]-3-one; 4',5'-Dibromofluorescein; and its sodium salt
- CAS
- 596-03-2/4372- 02-5
- Product type
- hair dye products
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- Orange
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9-yl) benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45370 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'- [9H]xanthene]-3-one; 4',5'-Dibromofluorescein; and its sodium salt
- CAS
- 596-03-2/4372- 02-5
- Product type
- hair dye products
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- Orange
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9-yl) benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45370 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'- [9H]xanthene]-3-one; 4',5'-Dibromofluorescein; and its sodium salt
- CAS
- 596-03-2/4372- 02-5
- Product type
- hair dye products
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
- Chemical name
- Orange
- Max concentration
- Not more than 1% 2-(6-hydroxy-3- oxo-3H-xanthen-9-yl) benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo- 3H-xanthen-9-yl)benzoic acid
- Product type
- All cosmetic products
- Color Index
- CI 45370 ( 2 )
Source: ASEAN Cosmetic Directive (HSA Dec 2025)
GCC6 regulations
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 596-03-2; 4372-02-5
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45370
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 596-03-2; 4372-02-5
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45370
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 596-03-2; 4372-02-5
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45370
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 596-03-2; 4372-02-5
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45370
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 596-03-2; 4372-02-5
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45370
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
- Chemical name
- 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments
- CAS
- 596-03-2; 4372-02-5
- Conditions of use
- Not more than 1% 2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid and 2% 2-(bromo-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid
- Color Index
- CI 45370
Source: GSO 1943:2024 (based on EU 1223/2009 IV)
EAEU5 regulations
- Chemical name
- 4',5'-дибром-3',6'-дигидроксиспиро[изобензофуран-1(3H),9'-[9H]ксантен]-3-он и его нерастворимые бария, стронция и циркония лаки, соли и пигменты 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил) бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45370
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 75)
- Chemical name
- 4',5'-дибром-3',6'-дигидроксиспиро[изобензофуран-1(3H),9'-[9H]ксантен]-3-он и его нерастворимые бария, стронция и циркония лаки, соли и пигменты 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил) бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45370
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 75)
- Chemical name
- 4',5'-дибром-3',6'-дигидроксиспиро[изобензофуран-1(3H),9'-[9H]ксантен]-3-он и его нерастворимые бария, стронция и циркония лаки, соли и пигменты 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил) бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45370
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 75)
- Chemical name
- 4',5'-дибром-3',6'-дигидроксиспиро[изобензофуран-1(3H),9'-[9H]ксантен]-3-он и его нерастворимые бария, стронция и циркония лаки, соли и пигменты 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил) бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45370
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 75)
- Chemical name
- 4',5'-дибром-3',6'-дигидроксиспиро[изобензофуран-1(3H),9'-[9H]ксантен]-3-он и его нерастворимые бария, стронция и циркония лаки, соли и пигменты 4',5'-Dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one and its insoluble barium, strontium and zirconium lakes, salts and pigments
- Other conditions
- не более 1 процента 2-(6-гидрокси-3-окси-3H-ксантен-9-ил) бензойной кислоты и 2 процента 2-(бром-6-гидрокси-3-оксо-3H-ксантен-9-ил)бензойной кислоты
- Color Index
- 45370
Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 75)
Frequently Asked Questions
Is CI 45370 banned in any country?
Yes, CI 45370 is banned in Indonesia, Malaysia, Philippines, Singapore, Thailand, United Kingdom, Vietnam. Always check current regulations before formulating products for these markets.
What are the restrictions on CI 45370 in cosmetics?
CI 45370 is restricted or has conditions of use in UAE, Armenia, Bahrain, Belarus, European Union, Indonesia, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Restrictions may include maximum concentration limits, product type limitations, or mandatory labeling requirements. See the detailed regulations above for specifics.
Can I use CI 45370 in cosmetics?
CI 45370 is regulated in 21 markets. It is banned in Indonesia, Malaysia, Philippines, Singapore, Thailand, United Kingdom, Vietnam. It has restrictions in UAE, Armenia, Bahrain, Belarus, European Union, Indonesia, Kyrgyzstan, South Korea, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Use Formpli's free screening tool to check your full ingredient list against all 26 markets at once.
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Check Ingredients FreeThis information is for reference only and does not constitute legal or regulatory advice. Regulations change — always verify with official sources and consult a regulatory specialist before exporting cosmetic products. Data sourced from EU COSING, US FDA, Health Canada, MHLW Japan, MFDS Korea, ASEAN ACD, GCC SFDA, TGA Australia, ANVISA Brazil, EAEU TR CU, and Taiwan TFDA.