CI 21108

RestrictedCAS 5567-15-721 regulations across 21 markets

CI 21108 is a cosmetic ingredient classified as Colorant. Also known as CAS 5567-15-7. It is regulated in 21 markets including UAE, Armenia, Bahrain.

Also Known As

CAS Number
5567-15-7

Market Overview — 29 Markets

European Union1
United Kingdom1
United States
California
Maryland
Washington
Canada
Brazil1
South Korea
Japan
Taiwan1
Australia
Singapore1
Malaysia1
Thailand1
Indonesia1
Vietnam1
Philippines1
UAE1
Saudi Arabia1
Qatar1
Oman1
Kuwait1
Bahrain1
Russia1
Belarus1
Kazakhstan1
Armenia1
Kyrgyzstan1

Detailed Regulations

Europe2 regulations
European UnionRestrictedAnnex IV #48
Chemical name
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyramide]
CAS
5567-15-7
Product type
Rinse-off products
Conditions of use
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Color Index
CI 21108

Source: EC 1223/2009 Annex IV

United KingdomRestrictedAnnex IV #48
Chemical name
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyramide]
Product type
Rinse-off products
Other conditions
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Color Index
21108

Source: UK retained EC 1223/2009 Annex IV

Americas1 regulation
BrazilRestrictedAnnex RDC_628 #CI_21108
Product type
brief_contact_only
Conditions of use
Application fields: brief_contact_only | Limitations: Concentração máxima de 3,3'-dimetilbenzidina: 5 ppm no corante
Color Index
CI 21108

Source: ANVISA RDC 628

East Asia & Oceania1 regulation
TaiwanRestrictedAnnex Colorants List #48
Chemical name
CI 21108
Product type
Scope 4: Cosmetic products intended to come into contact only briefly with the skin
Color Index
CI 21108

Source: TFDA Cosmetics Regulations

ASEAN6 regulations
SingaporeRestrictedAnnex ACD Annex IV (Colorants) #21108
Chemical name
Yellow
Max concentration
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Product type
Products with brief skin contact only
Color Index
CI 21108

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

MalaysiaRestrictedAnnex ACD Annex IV (Colorants) #21108
Chemical name
Yellow
Max concentration
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Product type
Products with brief skin contact only
Color Index
CI 21108

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

ThailandRestrictedAnnex ACD Annex IV (Colorants) #21108
Chemical name
Yellow
Max concentration
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Product type
Products with brief skin contact only
Color Index
CI 21108

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

IndonesiaRestrictedAnnex ACD Annex IV (Colorants) #21108
Chemical name
Yellow
Max concentration
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Product type
Products with brief skin contact only
Color Index
CI 21108

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

VietnamRestrictedAnnex ACD Annex IV (Colorants) #21108
Chemical name
Yellow
Max concentration
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Product type
Products with brief skin contact only
Color Index
CI 21108

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

PhilippinesRestrictedAnnex ACD Annex IV (Colorants) #21108
Chemical name
Yellow
Max concentration
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Product type
Products with brief skin contact only
Color Index
CI 21108

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

GCC6 regulations
UAERestrictedAnnex IV #48
Chemical name
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyramide]
CAS
5567-15-7
Product type
Rinse-off products
Conditions of use
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Color Index
CI 21108

Source: GSO 1943:2024 (based on EU 1223/2009 IV)

Saudi ArabiaRestrictedAnnex IV #48
Chemical name
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyramide]
CAS
5567-15-7
Product type
Rinse-off products
Conditions of use
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Color Index
CI 21108

Source: GSO 1943:2024 (based on EU 1223/2009 IV)

QatarRestrictedAnnex IV #48
Chemical name
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyramide]
CAS
5567-15-7
Product type
Rinse-off products
Conditions of use
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Color Index
CI 21108

Source: GSO 1943:2024 (based on EU 1223/2009 IV)

OmanRestrictedAnnex IV #48
Chemical name
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyramide]
CAS
5567-15-7
Product type
Rinse-off products
Conditions of use
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Color Index
CI 21108

Source: GSO 1943:2024 (based on EU 1223/2009 IV)

KuwaitRestrictedAnnex IV #48
Chemical name
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyramide]
CAS
5567-15-7
Product type
Rinse-off products
Conditions of use
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Color Index
CI 21108

Source: GSO 1943:2024 (based on EU 1223/2009 IV)

BahrainRestrictedAnnex IV #48
Chemical name
2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyramide]
CAS
5567-15-7
Product type
Rinse-off products
Conditions of use
Maximum 3,3'-dimethylbenzidine concentration in the colouring agent: 5 ppm
Color Index
CI 21108

Source: GSO 1943:2024 (based on EU 1223/2009 IV)

EAEU5 regulations
RussiaRestrictedAnnex 3 #48
Chemical name
2,2'-[(3,3'-дихлор[1,1'-бифенил]-4,4'-диил)бис(азо)]бис[N-(4-хлор-2,5-диметоксифенил)-3-оксобутирамид] 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyr-amide]
Product type
смываемая продукция
Other conditions
Максимальная концентрация 3,3'-диметилбензидина в красителе 5 ppm
Color Index
21108

Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 48)

BelarusRestrictedAnnex 3 #48
Chemical name
2,2'-[(3,3'-дихлор[1,1'-бифенил]-4,4'-диил)бис(азо)]бис[N-(4-хлор-2,5-диметоксифенил)-3-оксобутирамид] 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyr-amide]
Product type
смываемая продукция
Other conditions
Максимальная концентрация 3,3'-диметилбензидина в красителе 5 ppm
Color Index
21108

Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 48)

KazakhstanRestrictedAnnex 3 #48
Chemical name
2,2'-[(3,3'-дихлор[1,1'-бифенил]-4,4'-диил)бис(азо)]бис[N-(4-хлор-2,5-диметоксифенил)-3-оксобутирамид] 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyr-amide]
Product type
смываемая продукция
Other conditions
Максимальная концентрация 3,3'-диметилбензидина в красителе 5 ppm
Color Index
21108

Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 48)

ArmeniaRestrictedAnnex 3 #48
Chemical name
2,2'-[(3,3'-дихлор[1,1'-бифенил]-4,4'-диил)бис(азо)]бис[N-(4-хлор-2,5-диметоксифенил)-3-оксобутирамид] 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyr-amide]
Product type
смываемая продукция
Other conditions
Максимальная концентрация 3,3'-диметилбензидина в красителе 5 ppm
Color Index
21108

Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 48)

KyrgyzstanRestrictedAnnex 3 #48
Chemical name
2,2'-[(3,3'-дихлор[1,1'-бифенил]-4,4'-диил)бис(азо)]бис[N-(4-хлор-2,5-диметоксифенил)-3-оксобутирамид] 2,2'-[(3,3'-Dichloro[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[N-(4-chloro-2,5-dimethoxyphenyl)-3-oxobutyr-amide]
Product type
смываемая продукция
Other conditions
Максимальная концентрация 3,3'-диметилбензидина в красителе 5 ppm
Color Index
21108

Source: TR CU 009/2011 Annex 3 (Colorants) (Ref 48)

Frequently Asked Questions

Is CI 21108 banned in any country?

CI 21108 is not banned in any of the 26 markets tracked by Formpli. However, it may be subject to restrictions or conditions of use in some markets.

What are the restrictions on CI 21108 in cosmetics?

CI 21108 is restricted or has conditions of use in UAE, Armenia, Bahrain, Brazil, Belarus, European Union, Indonesia, Kyrgyzstan, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Restrictions may include maximum concentration limits, product type limitations, or mandatory labeling requirements. See the detailed regulations above for specifics.

Can I use CI 21108 in cosmetics?

CI 21108 is regulated in 21 markets. It has restrictions in UAE, Armenia, Bahrain, Brazil, Belarus, European Union, Indonesia, Kyrgyzstan, Kuwait, Kazakhstan, Malaysia, Oman, Philippines, Qatar, Russia, Saudi Arabia, Singapore, Thailand, Taiwan, United Kingdom, Vietnam. Use Formpli's free screening tool to check your full ingredient list against all 26 markets at once.

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This information is for reference only and does not constitute legal or regulatory advice. Regulations change — always verify with official sources and consult a regulatory specialist before exporting cosmetic products. Data sourced from EU COSING, US FDA, Health Canada, MHLW Japan, MFDS Korea, ASEAN ACD, GCC SFDA, TGA Australia, ANVISA Brazil, EAEU TR CU, and Taiwan TFDA.