4-NITROPHENYL AMINOETHYLUREA

RestrictedCAS 27080-42-819 regulations across 16 markets

4-NITROPHENYL AMINOETHYLUREA is a cosmetic ingredient classified as Hair Dyeing. Also known as CAS 27080-42-8. It is regulated in 16 markets including UAE, Bahrain, European Union.

Also Known As

CAS Number: 27080-42-8

Market Overview — 29 Markets

European Union1

United Kingdom2

United States

California

Maryland

Washington

Canada

Brazil

South Korea3

Japan

Taiwan1

Australia

Singapore1

Malaysia1

Thailand1

Indonesia1

Vietnam1

Philippines1

UAE1

Saudi Arabia1

Qatar1

Oman1

Kuwait1

Bahrain1

Russia

Belarus

Kazakhstan

Armenia

Kyrgyzstan

Detailed Regulations

Europe3 regulations

European UnionRestrictedAnnex III #249

Chemical name: 1-(.beta.-Ureidoethyl)amino-4-nitrobenzene
CAS: 27080-42-8
Max concentration: (b) 0.5%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products
Conditions of use: For (a) and (b): Hair colourants can cause severe allergic reactions Read and follow instructions
Other conditions: (a) After mixing under oxidative conditions the maximum concentratio applied to hair must not exceed 0.25% For (a) and (b): - Do not use with notrosating agents - Maximum nitrosamine content: 50 microgram/Kg -

Source: EC 1223/2009 Annex III

United KingdomRestrictedAnnex III #249

Chemical name: 1-(beta-Ureidoethyl)amino-4-nitrobenzene
CAS: 27080-42-8
Product type: (a) Hair dye substance in oxidative hair dye products
Conditions of use: (a) To be printed on the label: The mixing ratio. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “ black henna ” tattoos may increase your risk of allergy. Do not colour your hair if: you have a rash on your face or sensitive, irritated and damaged scalp, you have ever experienced any reaction after colouring your hair, you have experienced a reaction to a temporary “ black henna ” tattoo in the past. Hair colourants can cause severe allergic reactions.
Other conditions: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,25 % For (a) and (b): Do not use with nitrosating agents Maximum nitrosamine content: 50 μg /kg Keep in nitrite-free containers

Source: UK retained EC 1223/2009 Annex III

United KingdomRestrictedAnnex III #249

Chemical name: 1-(beta-Ureidoethyl)amino-4-nitrobenzene
CAS: 27080-42-8
Max concentration: (b) 0,5 %
Product type: (b) Hair dye substance in non-oxidative hair dye products
Conditions of use: Max: (b) 0,5 % (a) To be printed on the label: The mixing ratio. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “ black henna ” tattoos may increase your risk of allergy. Do not colour your hair if: you have a rash on your face or sensitive, irritated and damaged scalp, you have ever experienced any reaction after colouring your hair, you have experienced a reaction to a temporary “ black henna ” tattoo in the past. Hair colourants can cause severe allergic reactions.
Other conditions: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,25 % For (a) and (b): Do not use with nitrosating agents Maximum nitrosamine content: 50 μg /kg Keep in nitrite-free containers

Source: UK retained EC 1223/2009 Annex III

AmericasNo restrictions

No specific restrictions for 4-NITROPHENYL AMINOETHYLUREA in United States, California, Maryland, Washington, Canada, Brazil.

East Asia & Oceania4 regulations

South KoreaRestrictedAnnex restricted #M338

Chemical name: 1-(Beta-Ureidoethyl)amino-4-nitrobenzene and its salts (e.g. 4-Nitrophenyl aminoethylurea) (with the exception of 4-Nitrophenyl aminoethylurea as the hair dye substance under the mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.25% (0.5% as non-oxidative conditions)
CAS: 27080-42-8

Source: MFDS Korea Cosmetics Regulation

South KoreaRestrictedAnnex restricted #M354

Chemical name: 4-Nitrophenyl Aminoethylurea

Source: MFDS Korea Cosmetics Regulation

South KoreaRestrictedAnnex restricted #M64

Chemical name: 1-(.beta.-Ureidoethyl)amino-4-nitrobenzene
CAS: 27080-42-8

Source: MFDS Korea Cosmetics Regulation

TaiwanRestrictedAnnex Restricted Ingredients List #118

Chemical name: 1-(beta-Ureidoethyl)amino-4-nitrobenzene
CAS: 27080-42-8
Max concentration: (a)0.25% (b)0.5%
Product type: (a)Oxidative hair dye products (b)Non-oxidative hair dye products
Conditions of use: Prohibited to use with nitrosating agents; Maximum nitrosamine content: 50 mg/kg(ppb); Must be stored in a nitrite free container.

Source: TFDA Cosmetics Regulations

ASEAN6 regulations

SingaporeRestrictedAnnex ACD Annex III (Restricted) #251

Chemical name: 1-(beta-Ureidoethyl)amino-4- nitrobenzene / 4-Nitrophenyl aminoethylurea
CAS: 27080-42-8
Max concentration: b) 0.5%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.25% For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg (21) • Keep in nitrite-free containers The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past (a) and (b) Do not use to dye eyelashes or eyebrows

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

MalaysiaRestrictedAnnex ACD Annex III (Restricted) #251

Chemical name: 1-(beta-Ureidoethyl)amino-4- nitrobenzene / 4-Nitrophenyl aminoethylurea
CAS: 27080-42-8
Max concentration: b) 0.5%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.25% For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg (21) • Keep in nitrite-free containers The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past (a) and (b) Do not use to dye eyelashes or eyebrows

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

ThailandRestrictedAnnex ACD Annex III (Restricted) #251

Chemical name: 1-(beta-Ureidoethyl)amino-4- nitrobenzene / 4-Nitrophenyl aminoethylurea
CAS: 27080-42-8
Max concentration: b) 0.5%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.25% For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg (21) • Keep in nitrite-free containers The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past (a) and (b) Do not use to dye eyelashes or eyebrows

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

IndonesiaRestrictedAnnex ACD Annex III (Restricted) #251

Chemical name: 1-(beta-Ureidoethyl)amino-4- nitrobenzene / 4-Nitrophenyl aminoethylurea
CAS: 27080-42-8
Max concentration: b) 0.5%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.25% For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg (21) • Keep in nitrite-free containers The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past (a) and (b) Do not use to dye eyelashes or eyebrows

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

VietnamRestrictedAnnex ACD Annex III (Restricted) #251

Chemical name: 1-(beta-Ureidoethyl)amino-4- nitrobenzene / 4-Nitrophenyl aminoethylurea
CAS: 27080-42-8
Max concentration: b) 0.5%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.25% For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg (21) • Keep in nitrite-free containers The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past (a) and (b) Do not use to dye eyelashes or eyebrows

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

PhilippinesRestrictedAnnex ACD Annex III (Restricted) #251

Chemical name: 1-(beta-Ureidoethyl)amino-4- nitrobenzene / 4-Nitrophenyl aminoethylurea
CAS: 27080-42-8
Max concentration: b) 0.5%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.25% For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg (21) • Keep in nitrite-free containers The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past (a) and (b) Do not use to dye eyelashes or eyebrows

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

GCC6 regulations

UAERestrictedAnnex III #249

Chemical name: 1-(.beta.-Ureidoethyl)amino-4-nitrobenzene
CAS: 27080-42-8
Max concentration: (b) 0.5%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products
Conditions of use: For (a) and (b): Hair colourants can cause severe allergic reactions Read and follow instructions
Other conditions: (a) After mixing under oxidative conditions the maximum concentratio applied to hair must not exceed 0.25% For (a) and (b): - Do not use with notrosating agents - Maximum nitrosamine content: 50 microgram/Kg -