2-CHLORO-6-ETHYLAMINO-4-NITROPHENOL

RestrictedCAS 131657-78-826 regulations across 16 markets

2-CHLORO-6-ETHYLAMINO-4-NITROPHENOL is a cosmetic ingredient classified as Hair Dyeing. Also known as CAS 131657-78-8. It is regulated in 16 markets including UAE, Bahrain, European Union.

Also Known As

CAS Number: 131657-78-8

Market Overview — 29 Markets

European Union2

United Kingdom3

United States

California

Maryland

Washington

Canada

Brazil

South Korea2

Japan

Taiwan1

Australia

Singapore1

Malaysia1

Thailand1

Indonesia1

Vietnam1

Philippines1

UAE2

Saudi Arabia2

Qatar2

Oman2

Kuwait2

Bahrain2

Russia

Belarus

Kazakhstan

Armenia

Kyrgyzstan

Detailed Regulations

Europe5 regulations

European UnionRestrictedAnnex III #201

Chemical name: Phenol, 2-Chloro-6-(ethylamino)-4-nitro- (see note 17)
CAS: 131657-78-8
Max concentration: 3.0%
Product type: a) Hair dye substance in oxidative hair dye product b) Hair dye substance in non-oxidative hair dye product
Conditions of use: Can cause allergic reaction
Other conditions: a) Afther mixing oxidative conditions the maximum concentration applied to hair must not exceed 1,5% (a) and (b) - Do not use with nitrosating systems - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers

Source: EC 1223/2009 Annex III

European UnionRestrictedAnnex III #251

Chemical name: Phenol, 2-Chloro-6-(ethylamino)-4-nitro- and its salts
CAS: 131657-78-8
Max concentration: (a) 3.0% (b) 3.0%
Product type: (a) Oxidising colouring agents for hair dyeing (b) Non-oxidising colouring agents for hair dyeing
Other conditions: In combination with hydrogen peroxide the maximum use concentration upon application is 1.5% Not to be used after 31.12.2009

Source: EC 1223/2009 Annex III

United KingdomRestrictedAnnex III #201

Chemical name: Phenol, 2-Chloro-6-(ethylamino)-4-nitro-
CAS: 131657-78-8
Product type: (a) Hair dye substance in oxidative hair dye products
Conditions of use: (a) To be printed on the label: The mixing ratio. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “ black henna ” tattoos may increase your risk of allergy. Do not colour your hair if: you have a rash on your face or sensitive, irritated and damaged scalp, you have ever experienced any reaction after colouring your hair, you have experienced a reaction to a temporary “ black henna ” tattoo in the past. Hair colourants can cause severe allergic reactions.
Other conditions: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1,5 %

Source: UK retained EC 1223/2009 Annex III

United KingdomRestrictedAnnex III #201

Chemical name: Phenol, 2-Chloro-6-(ethylamino)-4-nitro-
CAS: 131657-78-8
Max concentration: (b) 3,0 %
Product type: (b) Hair dye substance in non-oxidative hair dye products
Conditions of use: Max: (b) 3,0 % (a) To be printed on the label: The mixing ratio. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “ black henna ” tattoos may increase your risk of allergy. Do not colour your hair if: you have a rash on your face or sensitive, irritated and damaged scalp, you have ever experienced any reaction after colouring your hair, you have experienced a reaction to a temporary “ black henna ” tattoo in the past. Hair colourants can cause severe allergic reactions.
Other conditions: (a) and (b): Do not use with nitrosating agents Maximum nitrosamine content: 50 μg /kg Keep in nitrite-free containers

Source: UK retained EC 1223/2009 Annex III

United KingdomRestrictedAnnex III #251

Chemical name: 2-(4-Amino-3-nitroanilino)ethanol
CAS: 24905-87-1
Max concentration: 1,0 %
Product type: Hair dye substance in non-oxidative hair dye products
Conditions of use: Max: 1,0 % Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “ black henna ” tattoos may increase your risk of allergy. Do not colour your hair if: you have a rash on your face or sensitive, irritated and damaged scalp, you have ever experienced any reaction after colouring your hair, you have experienced a reaction to a temporary “ black henna ” tattoo in the past. Hair colorants can cause severe allergic reactions.
Other conditions: Do not use with nitrosating agents Maximum nitrosamine content: 50 μg/kg Keep in nitrite-free containers

Source: UK retained EC 1223/2009 Annex III

AmericasNo restrictions

No specific restrictions for 2-CHLORO-6-ETHYLAMINO-4-NITROPHENOL in United States, California, Maryland, Washington, Canada, Brazil.

East Asia & Oceania3 regulations

South KoreaRestrictedAnnex restricted #M122

Chemical name: 2-Chloro-6-ethylamino-4-nitrophenol

Source: MFDS Korea Cosmetics Regulation

South KoreaRestrictedAnnex restricted #M236

Chemical name: 2-Chloro-6-ethylamino-4-nitrophenol and its salts (with the exception that After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5% (3.0% as non-oxidative conditions)
CAS: 131657-78-8

Source: MFDS Korea Cosmetics Regulation

TaiwanRestrictedAnnex Restricted Ingredients List #88

Chemical name: Phenol, 2-chloro-6-(ethylamino)-4-nitro-
CAS: 131657-78-8
Max concentration: (a)1.5% (b)3%
Product type: (a)Oxidative hair dye products (b)Non-oxidative hair dye products
Conditions of use: Prohibited to use with nitrosating agents; Maximum nitrosamine content: 50 mg/kg(ppb); Must be stored in a nitrite free container.

Source: TFDA Cosmetics Regulations

ASEAN6 regulations

SingaporeRestrictedAnnex ACD Annex III (Restricted) #201

Chemical name: Phenol, 2-Chloro-6-(ethylamino)-4- nitro- 2-Chloro-6-ethylamino-4-nitrophenol
CAS: 131657-78-8
Max concentration: (b) 3.0%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5% For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg (21) • Keep in nitrite-free containers The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a)The mixing ratio must be printed on the label. .Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary 'black henna' tattoo in the past (a) and (b) Do not use to

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

MalaysiaRestrictedAnnex ACD Annex III (Restricted) #201

Chemical name: Phenol, 2-Chloro-6-(ethylamino)-4- nitro- 2-Chloro-6-ethylamino-4-nitrophenol
CAS: 131657-78-8
Max concentration: (b) 3.0%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5% For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg (21) • Keep in nitrite-free containers The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a)The mixing ratio must be printed on the label. .Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary 'black henna' tattoo in the past (a) and (b) Do not use to

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

ThailandRestrictedAnnex ACD Annex III (Restricted) #201

Chemical name: Phenol, 2-Chloro-6-(ethylamino)-4- nitro- 2-Chloro-6-ethylamino-4-nitrophenol
CAS: 131657-78-8
Max concentration: (b) 3.0%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5% For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg (21) • Keep in nitrite-free containers The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a)The mixing ratio must be printed on the label. .Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary 'black henna' tattoo in the past (a) and (b) Do not use to

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

IndonesiaRestrictedAnnex ACD Annex III (Restricted) #201

Chemical name: Phenol, 2-Chloro-6-(ethylamino)-4- nitro- 2-Chloro-6-ethylamino-4-nitrophenol
CAS: 131657-78-8
Max concentration: (b) 3.0%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5% For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg (21) • Keep in nitrite-free containers The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a)The mixing ratio must be printed on the label. .Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary 'black henna' tattoo in the past (a) and (b) Do not use to

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

VietnamRestrictedAnnex ACD Annex III (Restricted) #201

Chemical name: Phenol, 2-Chloro-6-(ethylamino)-4- nitro- 2-Chloro-6-ethylamino-4-nitrophenol
CAS: 131657-78-8
Max concentration: (b) 3.0%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5% For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg (21) • Keep in nitrite-free containers The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a)The mixing ratio must be printed on the label. .Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary 'black henna' tattoo in the past (a) and (b) Do not use to

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

PhilippinesRestrictedAnnex ACD Annex III (Restricted) #201

Chemical name: Phenol, 2-Chloro-6-(ethylamino)-4- nitro- 2-Chloro-6-ethylamino-4-nitrophenol
CAS: 131657-78-8
Max concentration: (b) 3.0%
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.5% For (a) and (b): • Do not use with nitrosating agents • Maximum nitrosamine content: 50 μg/kg (21) • Keep in nitrite-free containers The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a)The mixing ratio must be printed on the label. .Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: - you have a rash on your face or sensitive, irritated and damaged scalp, - you have ever experienced any reaction after colouring your hair, - you have experienced a reaction to a temporary 'black henna' tattoo in the past (a) and (b) Do not use to

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

GCC12 regulations

UAERestrictedAnnex III #201

Chemical name: Phenol, 2-Chloro-6-(ethylamino)-4-nitro- (see note 17)
CAS: 131657-78-8
Max concentration: 3.0%
Product type: a) Hair dye substance in oxidative hair dye product b) Hair dye substance in non-oxidative hair dye product
Conditions of use: Can cause allergic reaction
Other conditions: a) Afther mixing oxidative conditions the maximum concentration applied to hair must not exceed 1,5% (a) and (b) - Do not use with nitrosating systems - Maximum nitrosamine content: 50 microgram/kg - Keep in nitrite-free containers