1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE

RestrictedCAS 81892-72-016 regulations across 14 markets

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE is a cosmetic ingredient classified as Hair Dyeing. Also known as CAS 81892-72-0. It is regulated in 14 markets including UAE, Bahrain, European Union.

Also Known As

CAS Number: 81892-72-0

Market Overview — 29 Markets

European Union1

United Kingdom3

United States

California

Maryland

Washington

Canada

Brazil

South Korea

Japan

Taiwan

Australia

Singapore1

Malaysia1

Thailand1

Indonesia1

Vietnam1

Philippines1

UAE1

Saudi Arabia1

Qatar1

Oman1

Kuwait1

Bahrain1

Russia

Belarus

Kazakhstan

Armenia

Kyrgyzstan

Detailed Regulations

Europe4 regulations

European UnionRestrictedAnnex III #202

Chemical name: 4,4'-[1,3-Propanediylbis(oxy)]bisbenzene-1,3-diamine and its tetrahydrochloride salt (see note 17)
CAS: 81892-72-0 - 74918-21-1
Product type: (a) Hair dye substance in oxidative hair dye products
Conditions of use: (a) The mixing ratio: Hair colorants can cause severe allergic reactions. (b) Can cause allergic reaction
Other conditions: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.2% calculated as free base (1.8% as tetrahydrochloride salt).

Source: EC 1223/2009 Annex III

United KingdomRestrictedAnnex III #202

Chemical name: See 226

Source: UK retained EC 1223/2009 Annex III

United KingdomRestrictedAnnex III #226

Chemical name: 4,4′-[1,3-Propanediylbis(oxy)]bisbenzene-1,3-diamine and its tetrahydrochloride salt
CAS: 81892-72-0 / 74918-21-1
Product type: (a) Hair dye substance in oxidative hair dye products
Conditions of use: (a) To be printed on the label: The mixing ratio. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary “ black henna ” tattoos may increase your risk of allergy. Do not colour your hair if: you have a rash on your face or sensitive, irritated and damaged scalp, you have ever experienced any reaction after colouring your hair, you have experienced a reaction to a temporary “ black henna ” tattoo in the past. Hair colourants can cause severe allergic reactions.
Other conditions: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1,2 % calculated as free base (1,8 % as tetrahydrochloride salt).

Source: UK retained EC 1223/2009 Annex III

United KingdomRestrictedAnnex III #226

Chemical name: 4,4′-[1,3-Propanediylbis(oxy)]bisbenzene-1,3-diamine and its tetrahydrochloride salt
CAS: 81892-72-0 / 74918-21-1
Max concentration: (b) 1,2 % as free base (1,8 % as tetrahydrochloride salt)
Product type: (b) Hair dye substance in non-oxidative hair dye products
Conditions of use: Max: (b) 1,2 % as free base (1,8 % as tetrahydrochloride salt) (b) Can cause allergic reaction
Other conditions: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1,2 % calculated as free base (1,8 % as tetrahydrochloride salt).

Source: UK retained EC 1223/2009 Annex III

AmericasNo restrictions

No specific restrictions for 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE in United States, California, Maryland, Washington, Canada, Brazil.

East Asia & OceaniaNo restrictions

No specific restrictions for 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE in South Korea, Japan, Taiwan, Australia.

ASEAN6 regulations

SingaporeRestrictedAnnex ACD Annex III (Restricted) #202

Chemical name: 4,4′-[1,3- Propanediylbis(oxy)]bisbenzene-1,3- diamine and its tetrahydrochloride salt 1,3-bis-(2,4-Diaminophenoxy) propane,3-bis-(2,4-Diaminophenoxy) propane HCl
CAS: 81892-72-0
Max concentration: (b) 1.2% as free base (1.8% as tetrahydro chloride salt)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.2% calculated as free base (1.8% as tetrahydrochloride salt). The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past. Do not use to dye eyelashes or eyebrows (b) Can cause allergic reaction Do not use to dye eyelashes

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

MalaysiaRestrictedAnnex ACD Annex III (Restricted) #202

Chemical name: 4,4′-[1,3- Propanediylbis(oxy)]bisbenzene-1,3- diamine and its tetrahydrochloride salt 1,3-bis-(2,4-Diaminophenoxy) propane,3-bis-(2,4-Diaminophenoxy) propane HCl
CAS: 81892-72-0
Max concentration: (b) 1.2% as free base (1.8% as tetrahydro chloride salt)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.2% calculated as free base (1.8% as tetrahydrochloride salt). The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past. Do not use to dye eyelashes or eyebrows (b) Can cause allergic reaction Do not use to dye eyelashes

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

ThailandRestrictedAnnex ACD Annex III (Restricted) #202

Chemical name: 4,4′-[1,3- Propanediylbis(oxy)]bisbenzene-1,3- diamine and its tetrahydrochloride salt 1,3-bis-(2,4-Diaminophenoxy) propane,3-bis-(2,4-Diaminophenoxy) propane HCl
CAS: 81892-72-0
Max concentration: (b) 1.2% as free base (1.8% as tetrahydro chloride salt)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.2% calculated as free base (1.8% as tetrahydrochloride salt). The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past. Do not use to dye eyelashes or eyebrows (b) Can cause allergic reaction Do not use to dye eyelashes

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

IndonesiaRestrictedAnnex ACD Annex III (Restricted) #202

Chemical name: 4,4′-[1,3- Propanediylbis(oxy)]bisbenzene-1,3- diamine and its tetrahydrochloride salt 1,3-bis-(2,4-Diaminophenoxy) propane,3-bis-(2,4-Diaminophenoxy) propane HCl
CAS: 81892-72-0
Max concentration: (b) 1.2% as free base (1.8% as tetrahydro chloride salt)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.2% calculated as free base (1.8% as tetrahydrochloride salt). The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past. Do not use to dye eyelashes or eyebrows (b) Can cause allergic reaction Do not use to dye eyelashes

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

VietnamRestrictedAnnex ACD Annex III (Restricted) #202

Chemical name: 4,4′-[1,3- Propanediylbis(oxy)]bisbenzene-1,3- diamine and its tetrahydrochloride salt 1,3-bis-(2,4-Diaminophenoxy) propane,3-bis-(2,4-Diaminophenoxy) propane HCl
CAS: 81892-72-0
Max concentration: (b) 1.2% as free base (1.8% as tetrahydro chloride salt)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.2% calculated as free base (1.8% as tetrahydrochloride salt). The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past. Do not use to dye eyelashes or eyebrows (b) Can cause allergic reaction Do not use to dye eyelashes

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

PhilippinesRestrictedAnnex ACD Annex III (Restricted) #202

Chemical name: 4,4′-[1,3- Propanediylbis(oxy)]bisbenzene-1,3- diamine and its tetrahydrochloride salt 1,3-bis-(2,4-Diaminophenoxy) propane,3-bis-(2,4-Diaminophenoxy) propane HCl
CAS: 81892-72-0
Max concentration: (b) 1.2% as free base (1.8% as tetrahydro chloride salt)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted.
Conditions of use: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.2% calculated as free base (1.8% as tetrahydrochloride salt). The free base and salts of this hair colouring ingredient, unless prohibited under Annex II, are permitted for use. The direction for use 'wear suitable gloves' must be included in label or leaflet text. | Label: (a) The mixing ratio must be printed on the label. Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary 'black henna' tattoos may increase your risk of allergy. Do not colour your hair if: • you have a rash on your face or sensitive, irritated and damaged scalp, • you have ever experienced any reaction after colouring your hair, • you have experienced a reaction to a temporary 'black henna' tattoo in the past. Do not use to dye eyelashes or eyebrows (b) Can cause allergic reaction Do not use to dye eyelashes

Source: ASEAN Cosmetic Directive (HSA Dec 2025)

GCC6 regulations

UAERestrictedAnnex III #202

Chemical name: 4,4'-[1,3-Propanediylbis(oxy)]bisbenzene-1,3-diamine and its tetrahydrochloride salt (see note 17)
CAS: 81892-72-0 - 74918-21-1
Product type: (a) Hair dye substance in oxidative hair dye products
Conditions of use: (a) The mixing ratio: Hair colorants can cause severe allergic reactions. (b) Can cause allergic reaction
Other conditions: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1.2% calculated as free base (1.8% as tetrahydrochloride salt).